Genetics and neurobiology of eating disorders

CM Bulik, JRI Coleman, JA Hardaway… - Nature …, 2022 - nature.com
Eating disorders (anorexia nervosa, bulimia nervosa and binge-eating disorder) are a
heterogeneous class of complex illnesses marked by weight and appetite dysregulation …

Cortico-striatal-thalamic loop circuits of the salience network: a central pathway in psychiatric disease and treatment

SK Peters, K Dunlop, J Downar - Frontiers in systems neuroscience, 2016 - frontiersin.org
The salience network (SN) plays a central role in cognitive control by integrating sensory
input to guide attention, attend to motivationally salient stimuli and recruit appropriate …

Can interoception improve the pragmatic search for biomarkers in psychiatry?

SS Khalsa, RC Lapidus - Frontiers in psychiatry, 2016 - frontiersin.org
Disrupted interoception is a prominent feature of the diagnostic classification of several
psychiatric disorders. However, progress in understanding the interoceptive basis of these …

The neurobiology of eating disorders

GKW Frank, ME Shott… - Child and adolescent …, 2019 - pmc.ncbi.nlm.nih.gov
Methods This article provides a state-of-the-art review of current neurobiological research in
eating disorders in children, adolescents and young adults up to 25 years of age when brain …

Structural neuroimaging of anorexia nervosa: future directions in the quest for mechanisms underlying dynamic alterations

JA King, GKW Frank, PM Thompson, S Ehrlich - Biological psychiatry, 2018 - Elsevier
Anorexia nervosa (AN) is a serious eating disorder characterized by self-starvation and
extreme weight loss. Pseudoatrophic brain changes are often readily visible in individual …

Neuroendocrinology and brain imaging of reward in eating disorders: A possible key to the treatment of anorexia nervosa and bulimia nervosa

AM Monteleone, G Castellini, U Volpe, V Ricca… - Progress in neuro …, 2018 - Elsevier
Anorexia nervosa and bulimia nervosa are severe eating disorders whose etiopathogenesis
is still unknown. Clinical features suggest that eating disorders may develop as reward …

The neurobiological reward system and binge eating: A critical systematic review of neuroimaging studies

N Leenaerts, D Jongen, J Ceccarini… - … Journal of Eating …, 2022 - Wiley Online Library
Objective Changes in reward processing are hypothesized to play a role in the onset and
maintenance of binge eating (BE). However, despite an increasing number of studies …

Structural and functional brain alterations in anorexia nervosa: A multimodal meta‐analysis of neuroimaging studies

T Su, J Gong, G Tang, S Qiu, P Chen… - Human brain …, 2021 - Wiley Online Library
Anorexia nervosa (AN) is a complex psychiatric disorder with poorly understood etiology.
Numerous voxel‐based morphometry (VBM) and resting‐state functional imaging studies …

Brain morphological changes in adolescent and adult patients with anorexia nervosa

J Seitz, B Herpertz-Dahlmann, K Konrad - Journal of neural transmission, 2016 - Springer
Gray matter (GM) and white matter (WM) volume loss occur in the brains of patients with
acute anorexia nervosa (AN) and improve again upon weight restoration. Adolescence is an …

Hunger does not motivate reward in women remitted from anorexia nervosa

CE Wierenga, A Bischoff-Grethe, AJ Melrose, Z Irvine… - Biological …, 2015 - Elsevier
Background Hunger enhances sensitivity to reward, yet individuals with anorexia nervosa
(AN) are not motivated to eat when starved. This study investigated brain response to …