Novel therapeutic applications of cardiac glycosides
Cardiac glycosides are a diverse family of naturally derived compounds that bind to and
inhibit Na+/K+-ATPase. Members of this family have been in clinical use for many years for …
inhibit Na+/K+-ATPase. Members of this family have been in clinical use for many years for …
Ginsenosides as Anticancer Agents: In vitro and in vivo Activities, Structure–Activity Relationships, and Molecular Mechanisms of Action
Conventional chemotherapeutic agents are often toxic not only to tumor cells but also to
normal cells, limiting their therapeutic use in the clinic. Novel natural product anticancer …
normal cells, limiting their therapeutic use in the clinic. Novel natural product anticancer …
Oxime ligation: a chemoselective click‐type reaction for accessing multifunctional biomolecular constructs
There is a growing need for biocompatible click reactions in order to prepare multifunctional
conjugates, which are valuable molecules for innovative biomedical applications. In this …
conjugates, which are valuable molecules for innovative biomedical applications. In this …
Anticancer steroids: linking natural and semi-synthetic compounds
JAR Salvador, JFS Carvalho, MAC Neves… - Natural product …, 2013 - pubs.rsc.org
Covering: up to 2012 Steroids, a widespread class of natural organic compounds occurring
in animals, plants and fungi, have shown great therapeutic value for a broad array of …
in animals, plants and fungi, have shown great therapeutic value for a broad array of …
Natural‐product sugar biosynthesis and enzymatic glycodiversification
Many biologically active small‐molecule natural products produced by microorganisms
derive their activities from sugar substituents. Changing the structures of these sugars can …
derive their activities from sugar substituents. Changing the structures of these sugars can …
Cardiotonic steroids on the road to anti-cancer therapy
T Mijatovic, E Van Quaquebeke, B Delest… - … et Biophysica Acta (BBA …, 2007 - Elsevier
The sodium pump, Na+/K+-ATPase, could be an important target for the development of anti-
cancer drugs as it serves as a versatile signal transducer, it is a key player in cell adhesion …
cancer drugs as it serves as a versatile signal transducer, it is a key player in cell adhesion …
Enzymatic methods for glyco (diversification/randomization) of drugs and small molecules
Covering: up to the end of May 2011 Glyco (randomization/diversification) is a term that
encompasses strategies to diversify a core drug scaffold via enzymatic glycosylation to …
encompasses strategies to diversify a core drug scaffold via enzymatic glycosylation to …
American ginseng: potential structure–function relationship in cancer chemoprevention
Ginseng has a prominent position on the list of best-selling herbal products in the world, and
its main active constituents are thought to be ginsenosides. Compared with the long history …
its main active constituents are thought to be ginsenosides. Compared with the long history …
Functional and Structural Dissection of a Plant Steroid 3-O-Glycosyltransferase Facilitated the Engineering Enhancement of Sugar Donor Promiscuity
W Huang, Y He, R Jiang, Z Deng, F Long - Acs Catalysis, 2022 - ACS Publications
Cardiotonic steroids (CTSs) are ancient and effective clinical drugs for treating heart failure.
Glycosylation of the CTS, especially at the C-3 position, is of great significance in nowadays …
Glycosylation of the CTS, especially at the C-3 position, is of great significance in nowadays …
A Reagent-Controlled SN2-Glycosylation for the Direct Synthesis of β-Linked 2-Deoxy-Sugars
JP Issa, CS Bennett - Journal of the American Chemical Society, 2014 - ACS Publications
The efficient and stereoselective construction of glycosidic linkages remains one of the most
formidable challenges in organic chemistry. This is especially true in cases such as β-linked …
formidable challenges in organic chemistry. This is especially true in cases such as β-linked …