Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease
Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …
dependent dementia. There is currently no effective treatment for AD, which may be …
Inflammation: the link between comorbidities, genetics, and Alzheimer's disease
Alzheimer's disease (AD) is a neurodegenerative disorder, most cases of which lack a clear
causative event. This has made the disease difficult to characterize and, thus, diagnose …
causative event. This has made the disease difficult to characterize and, thus, diagnose …
The endosomal-lysosomal system: from acidification and cargo sorting to neurodegeneration
YB Hu, EB Dammer, RJ Ren, G Wang - Translational neurodegeneration, 2015 - Springer
The endosomal-lysosomal system is made up of a set of intracellular membranous
compartments that dynamically interconvert, which is comprised of early endosomes …
compartments that dynamically interconvert, which is comprised of early endosomes …
Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy
G Bu - Nature Reviews Neuroscience, 2009 - nature.com
The vast majority of Alzheimer's disease (AD) cases are late-onset and their development is
probably influenced by both genetic and environmental risk factors. A strong genetic risk …
probably influenced by both genetic and environmental risk factors. A strong genetic risk …
A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity
Epidemiological studies have documented a reduced prevalence of Alzheimer's disease
among users of nonsteroidal anti-inflammatory drugs (NSAIDs),,,,. It has been proposed that …
among users of nonsteroidal anti-inflammatory drugs (NSAIDs),,,,. It has been proposed that …
Amyloid-beta: a crucial factor in Alzheimer's disease
Alzheimer's disease (AD) is the most prevalent form of dementia which affects people older
than 60 years of age. In AD, the dysregulation of the amyloid-beta (Aβ) level leads to the …
than 60 years of age. In AD, the dysregulation of the amyloid-beta (Aβ) level leads to the …
LRP: a multifunctional scavenger and signaling receptor
J Herz, DK Strickland - The Journal of clinical investigation, 2001 - Am Soc Clin Investig
The LDL receptor–related protein (LRP) is larger than but structurally similar to other
members of the LDL receptor gene family, an ancient family of endocytic receptors (1–3) …
members of the LDL receptor gene family, an ancient family of endocytic receptors (1–3) …
Insulin in the brain: there and back again
Insulin performs unique functions within the CNS. Produced nearly exclusively by the
pancreas, insulin crosses the blood–brain barrier (BBB) using a saturable transporter …
pancreas, insulin crosses the blood–brain barrier (BBB) using a saturable transporter …
LRP/amyloid β-peptide interaction mediates differential brain efflux of Aβ isoforms
R Deane, Z Wu, A Sagare, J Davis, S Du Yan, K Hamm… - Neuron, 2004 - cell.com
LRP (low-density lipoprotein receptor-related protein) is linked to Alzheimer's disease (AD).
Here, we report amyloid β-peptide Aβ40 binds to immobilized LRP clusters II and IV with …
Here, we report amyloid β-peptide Aβ40 binds to immobilized LRP clusters II and IV with …
Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death
DA Butterfield, A Castegna, CM Lauderback… - Neurobiology of …, 2002 - Elsevier
Amyloid β-peptide [Aβ (1–42)] is central to the pathogenesis of Alzheimer's disease (AD),
and the AD brain is under intense oxidative stress, including membrane lipid peroxidation …
and the AD brain is under intense oxidative stress, including membrane lipid peroxidation …