Lung repair and regeneration: Advanced models and insights into human disease
The respiratory system acts as both the primary site of gas exchange and an important
sensor and barrier to the external environment. The increase in incidences of respiratory …
sensor and barrier to the external environment. The increase in incidences of respiratory …
[HTML][HTML] An expanded universe of cancer targets
The characterization of cancer genomes has provided insight into somatically altered genes
across tumors, transformed our understanding of cancer biology, and enabled tailoring of …
across tumors, transformed our understanding of cancer biology, and enabled tailoring of …
Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication
Multiple coronaviruses have emerged independently in the past 20 years that cause lethal
human diseases. Although vaccine development targeting these viruses has been …
human diseases. Although vaccine development targeting these viruses has been …
Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets
KM Haas, MJ McGregor, M Bouhaddou… - Nature …, 2023 - nature.com
Abstract Influenza A Virus (IAV) is a recurring respiratory virus with limited availability of
antiviral therapies. Understanding host proteins essential for IAV infection can identify …
antiviral therapies. Understanding host proteins essential for IAV infection can identify …
RNA G-quadruplex in TMPRSS2 reduces SARS-CoV-2 infection
G Liu, W Du, X Sang, Q Tong, Y Wang, G Chen… - Nature …, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to have
devastating consequences worldwide. Recently, great efforts have been made to identify …
devastating consequences worldwide. Recently, great efforts have been made to identify …
[HTML][HTML] SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid (N) protein is
essential for viral replication, making it a promising target for antiviral drug and vaccine …
essential for viral replication, making it a promising target for antiviral drug and vaccine …
DeepIPs: comprehensive assessment and computational identification of phosphorylation sites of SARS-CoV-2 infection using a deep learning-based approach
The rapid spread of SARS-CoV-2 infection around the globe has caused a massive health
and socioeconomic crisis. Identification of phosphorylation sites is an important step for …
and socioeconomic crisis. Identification of phosphorylation sites is an important step for …
Targeting the coronavirus nucleocapsid protein through GSK-3 inhibition
The coronaviruses responsible for severe acute respiratory syndrome (SARS-CoV), COVID-
19 (SARS-CoV-2), Middle East respiratory syndrome-CoV, and other coronavirus infections …
19 (SARS-CoV-2), Middle East respiratory syndrome-CoV, and other coronavirus infections …
SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injury
ML Wu, FL Liu, J Sun, X Li, XY He, HY Zheng… - … and Targeted Therapy, 2021 - nature.com
Abstract SARS-CoV-2 infection-induced hyper-inflammation links to the acute lung injury
and COVID-19 severity. Identifying the primary mediators that initiate the uncontrolled …
and COVID-19 severity. Identifying the primary mediators that initiate the uncontrolled …
Rapid endotheliitis and vascular damage characterize SARS‐CoV‐2 infection in a human lung‐on‐chip model
Severe cases of SARS‐CoV‐2 infection are characterized by hypercoagulopathies and
systemic endotheliitis of the lung microvasculature. The dynamics of vascular damage, and …
systemic endotheliitis of the lung microvasculature. The dynamics of vascular damage, and …