Polyethlyenimine (PEI) was introduced 1995 as a cationic polymer for nucleic acid delivery.
PEI and its derivatives are extensively used in basic research and as reference formulations …

RNA interference is a naturally occurring endogenous regulatory process where short
double-stranded RNA causes sequence-specific posttranscriptional gene silencing. Small …

We investigated the effects of inhibitors of clathrin-mediated endocytosis (chlorpromazine
and K+ depletion) and of caveolae-mediated uptake (filipin and genistein) on internalization …

Nanocarriers with positive surface charges are known for their toxicity which has limited their
clinical applications. The mechanism underlying their toxicity, such as the induction of …

Background Efficient gene transfer is a major challenge for non‐viral gene therapy.
Understanding how non‐viral vectors initiate gene expression could lead to the …

The polycation polyethylenimine (PEI) has recently been widely employed for the design of
DNA delivery vehicles. Gene delivery using PEI involves condensation of DNA into compact …

Gene and antisense/ribozyme therapy possesses tremendous potential for the successful
treatment of genetically based diseases, such as cancer. Several cancer gene therapy …

Influenza A virus infection is a major source of morbidity and mortality worldwide. Because
the effectiveness of existing vaccines and antiviral drugs is limited, development of new …

A core− shell-type polyion complex (PIC) micelle with a disulfide cross-linked core was
prepared through the assembly of iminothiolane-modified poly (ethylene glycol)-block-poly (l …

Systemic application of positively charged polycation/DNA complexes has been shown to
result in predominant gene expression in the lungs. Targeting gene expression to other …