The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …

Genetics and environmental factors have important roles in autoimmune diseases but
neither has given us sufficient understanding of these mysterious diseases. Therefore, we …

We report for the first time the genomics of a nuclear compartment of the eukaryotic cell. 454
sequencing and microarray analysis revealed the pattern of nucleolus-associated chromatin …

The 274 tRNA genes in Saccharomyces cerevisiae are scattered throughout the linear maps
of the 16 chromosomes, but the genes are clustered at the nucleolus when compacted in the …

Transcription of the eukaryotic genomes is carried out by three distinct RNA polymerases I,
II, and III, whereby each polymerase is thought to independently transcribe a distinct set of …

Insulators help separate active chromatin domains from silenced ones. In yeast, gene
promoters act as insulators to block the spread of Sir and HP1 mediated silencing while in …

The nucleolus as site of ribosome biogenesis holds a pivotal role in cell metabolism. It is
composed of ribosomal DNA (rDNA), which is present as tandem arrays located in nucleolus …

Trypanosomes are a group of protozoan eukaryotes, many of which are major parasites of
humans and livestock. The genomes of trypanosomes and their modes of gene expression …

Cellular homeostasis requires the coordination of several machineries concurrently
engaged in the DNA. Wide-spread transcription can interfere with other processes, and …

We studied the nuclear topography of RNA transcription and DNA replication in mammalian
cell types with super-resolution fluorescence microscopy, which offers a resolution beyond …