Obesity II: establishing causal links between chemical exposures and obesity

JJ Heindel, S Howard, K Agay-Shay, JP Arrebola… - Biochemical …, 2022 - Elsevier
Obesity is a multifactorial disease with both genetic and environmental components. The
prevailing view is that obesity results from an imbalance between energy intake and …

[HTML][HTML] The potential roles of post-translational modifications of PPARγ in treating diabetes

X Ji, W Zhang, L Yin, Z Shi, J Luan, L Chen, L Liu - Biomolecules, 2022 - mdpi.com
The number of patients with type 2 diabetes mellitus (T2DM), which is mainly characterized
by insulin resistance and insulin secretion deficiency, has been soaring in recent years …

Adipogenic activity of chemicals used in plastic consumer products

J Völker, F Ashcroft, Å Vedøy… - … science & technology, 2022 - ACS Publications
Bisphenols and phthalates, chemicals frequently used in plastic products, promote obesity in
cell and animal models. However, these well-known metabolism-disrupting chemicals …

Triphenyl phosphate disturbs the lipidome and induces endoplasmic reticulum stress and apoptosis in JEG-3 cells

Y Wang, J Hong, M Shi, L Guo, L Liu, H Tang, X Liu - Chemosphere, 2021 - Elsevier
Triphenyl phosphate (TPP) is a frequently used aryl organophosphate flame retardant.
Epidemiological studies have shown that TPP and its metabolite diphenyl phosphate (DPP) …

[HTML][HTML] Lipid metabolic disturbance induced by triphenyl phosphate and hydroxy metabolite in HepG2 cells

J An, J Jiang, W Tang, Y Zhong, G Ren… - Ecotoxicology and …, 2023 - Elsevier
Triphenyl phosphate (TPHP) has been widely used as flame retardants and been detected
with increasing frequency in environment. TPHP can transform into mono-hydroxylated …

White-to-beige and back: Adipocyte conversion and transcriptional reprogramming

S Boychenko, VS Egorova, A Brovin, AD Egorov - Pharmaceuticals, 2024 - mdpi.com
Obesity has become a pandemic, as currently more than half a billion people worldwide are
obese. The etiology of obesity is multifactorial, and combines a contribution of hereditary …

Proteomic and phosphoproteomic profiling in heart failure with preserved ejection fraction (HFpEF)

M Valero-Muñoz, EL Saw, RM Hekman… - Frontiers in …, 2022 - frontiersin.org
Although the prevalence of heart failure with preserved ejection fraction (HFpEF) is
increasing, evidence-based therapies for HFpEF remain limited, likely due to an incomplete …

Adipogenic Effects of Cresyl Diphenyl Phosphate (Triphenyl Phosphate Alternative) through Peroxisome Proliferator-Activated Receptor Gamma Pathway: A …

L Sun, X Liu, J Du, H Yang, Y Lin, D Yu… - Environmental …, 2024 - ACS Publications
Cresyl diphenyl phosphate (CDP), a novel organophosphate ester (OPE), has been
detected in various environmental and human samples. However, there is very limited …

Remodeling on adipocytic physiology of organophosphorus esters in mature adipocytes

Y Liu, Y Le, M Xu, W Wang, H Chen, Q Zhang… - Environmental …, 2022 - Elsevier
The emerging endocrine disruption chemicals organophosphate esters (OPEs) pose high
risk of metabolic disruption. However, limited information is available on physiological …

Triphenyl phosphate interferes with the synthesis of steroid hormones through the PPARγ/CD36 pathway in human trophoblast JEG‐3 cells

Y Chen, Q Liu, Y Wang, M Jiang, J Zhang… - Environmental …, 2024 - Wiley Online Library
Triphenyl phosphate (TPhP), a chemical commonly found in human placenta and breast
milk, has been shown to disturb the endocrine system. Our previous study confirmed that …