Natural killer (NK) cells, a subgroup of innate lymphoid cells, act as the first line of defense
against cancer. Although some evidence shows that NK cells can develop in secondary …

Gut-associated lymphoid tissues (GALT) are the key antigen sampling and adaptive immune
inductive sites within the intestinal wall. Human GALT includes the multi-follicular Peyer's …

Despite their crucial role in health and disease, our knowledge of immune cells within
human tissues remains limited. We surveyed the immune compartment of 16 tissues from 12 …

The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that
signal through cell surface G protein‐coupled heptahelical chemokine receptors. They are …

Infancy and childhood are critical life stages for generating immune memory to protect
against pathogens; however, the timing, location, and pathways for memory development in …

The intestine represents the largest compartment of the immune system. It is continually
exposed to antigens and immunomodulatory agents from the diet and the commensal …

Memory T cells constitute the most abundant lymphocyte population in the body for the
majority of a person's lifetime; however, our understanding of memory T cell generation …

The chemokine superfamily consists of a large number of ligands and receptors. At first
glance, this family appears redundant and their ligand-receptor relationships promiscuous …

Leukocyte migration is a fundamental component of innate and adaptive immune responses
as it governs the recruitment and localization of these motile cells, which is crucial for …

Leukocyte trafficking to the small and large intestines is tightly controlled to maintain
intestinal immune homeostasis, mediate immune responses, and regulate inflammation. A …