Mechanical hallmarks of fibrotic microenvironments are both outcomes and causes of
fibrosis progression. Understanding how cells sense and transmit mechanical cues in the …

The toxicogenomics field aims to understand and predict toxicity by using 'omics' data in
order to study systems-level responses to compound treatments. In recent years there has …

In network and systems medicine, active module identification methods (AMIMs) are widely
used for discovering candidate molecular disease mechanisms. To this end, AMIMs …

Asparagine endopeptidase (AEP), also called legumain, is currently the only known cysteine
protease that specifically cleaves peptide bonds in asparaginyl residue in the mammalian …

Hepatic fibrosis is caused by the increased accumulation and improper degradation of
extracellular matrix (ECM) proteins in the liver. Hepatic stellate cells (HSCs) activation is a …

The seventh iteration of the reference genome assembly for Rattus norvegicus—mRatBN7.
2—corrects numerous misplaced segments and reduces base-level errors by approximately …

A long-term objective of network medicine is to replace our current, mainly phenotype-based
disease definitions by subtypes of health conditions corresponding to distinct …

Hepatocellular carcinoma (HCC) is a major health problem around the world. The
management of this disease is complicated by the lack of noninvasive diagnostic tools and …

The adverse outcome pathway (AOP) concept links molecular perturbations with organism
and population-level outcomes to support high-throughput toxicity (HTT) testing …

Legumain-deficient macrophages regulate inflammation and lipid metabolism in adipose tissues to
protect against diet-induced obesity - ScienceDirect Skip to main contentSkip to article Elsevier logo …