Src family kinases (SFKs): critical regulators of microglial homeostatic functions and neurodegeneration in Parkinson's and Alzheimer's diseases
c‐Src was the first protein kinase to be described as capable of phosphorylating tyrosine
residues. Subsequent identification of other tyrosine‐phosphorylating protein kinases with a …
residues. Subsequent identification of other tyrosine‐phosphorylating protein kinases with a …
Visualizing physiological parameters in cells and tissues using genetically encoded indicators for metabolites
The study of metabolism is undergoing a renaissance. Since the year 2002, over 50
genetically-encoded fluorescent indicators (GEFIs) have been introduced, capable of …
genetically-encoded fluorescent indicators (GEFIs) have been introduced, capable of …
Astrocyte-derived TNF and glutamate critically modulate microglia activation by methamphetamine
Methamphetamine (Meth) is a powerful illicit psychostimulant, widely used for recreational
purposes. Besides disrupting the monoaminergic system and promoting oxidative brain …
purposes. Besides disrupting the monoaminergic system and promoting oxidative brain …
The FGF/FGFR system in the microglial neuroinflammation with Borrelia burgdorferi: likely intersectionality with other neurological conditions
G Parthasarathy, MB Pattison, CC Midkiff - Journal of Neuroinflammation, 2023 - Springer
Background Lyme neuroborreliosis, caused by the bacterium Borrelia burgdorferi affects
both the central and peripheral nervous systems (CNS, PNS). The CNS manifestations …
both the central and peripheral nervous systems (CNS, PNS). The CNS manifestations …
RhoA balances microglial reactivity and survival during neuroinflammation
R Socodato, A Rodrigues-Santos… - Cell Death & …, 2023 - nature.com
Microglia are the largest myeloid cell population in the brain. During injury, disease, or
inflammation, microglia adopt different functional states primarily involved in restoring brain …
inflammation, microglia adopt different functional states primarily involved in restoring brain …
Daily alcohol intake triggers aberrant synaptic pruning leading to synapse loss and anxiety-like behavior
Alcohol abuse adversely affects the lives of millions of people worldwide. Deficits in synaptic
transmission and in microglial function are commonly found in human alcohol abusers and …
transmission and in microglial function are commonly found in human alcohol abusers and …
Cofilin mediates LPS-induced microglial cell activation and associated neurotoxicity through activation of NF-κB and JAK–STAT pathway
Microglial cells are activated in response to different types of injuries or stress in the CNS.
Such activation is necessary to get rid of the injurious agents and restore tissue …
Such activation is necessary to get rid of the injurious agents and restore tissue …
Microglia dysfunction caused by the loss of rhoa disrupts neuronal physiology and leads to neurodegeneration
Nervous tissue homeostasis requires the regulation of microglia activity. Using conditional
gene targeting in mice, we demonstrate that genetic ablation of the small GTPase Rhoa in …
gene targeting in mice, we demonstrate that genetic ablation of the small GTPase Rhoa in …
Selective A2A receptor antagonist prevents microglia-mediated neuroinflammation and protects retinal ganglion cells from high intraocular pressure–induced transient …
Glaucoma is a leading cause of vision loss and blindness worldwide, characterized by
chronic and progressive neuronal loss. Reactive microglial cells have been recognized as a …
chronic and progressive neuronal loss. Reactive microglial cells have been recognized as a …
The adenosine generating enzymes CD39/CD73 control microglial processes ramification in the mouse brain
Microglial cells invade the brain as amoeboid precursors and acquire a highly ramified
morphology in the postnatal brain. Microglia express all essential purinergic elements such …
morphology in the postnatal brain. Microglia express all essential purinergic elements such …