Phenotypic and functional heterogeneity arise among cancer cells within the same tumour
as a consequence of genetic change, environmental differences and reversible changes in …

Despite decades of research, brain tumours remain among the deadliest of all forms of
cancer. The ability of these tumours to resist almost all conventional and novel treatments …

Cancer has been a leading cause of death for decades. This dismal statistic has increased
efforts to prevent the disease or to detect it early, when treatment is less invasive, relatively …

Ependymal tumors across age groups are currently classified and graded solely by
histopathology. It is, however, commonly accepted that this classification scheme has limited …

Both solid tumours and leukaemias show considerable histological and functional
heterogeneity. It is widely accepted that genetic lesions have a major role in determining …

The differentiation of tumorigenic cancer stem cells into nontumorigenic cancer cells confers
heterogeneity to some cancers beyond that explained by clonal evolution or environmental …

Study of the origin and development of cerebellar tumours has been hampered by the
complexity and heterogeneity of cerebellar cells that change over the course of …

MicroRNAs (miRNAs) are small non-coding RNA molecules capable of negatively
regulating gene expression to control many cellular mechanisms. The miRTarBase …

Members of the nuclear factor-κB (NF-κB) family of transcriptional regulators are central
mediators of the cellular inflammatory response. Although constitutive NF-κB signalling is …

Medulloblastoma encompasses a collection of clinically and molecularly diverse tumour
subtypes that together comprise the most common malignant childhood brain tumour …