T cell activation
JE Smith-Garvin, GA Koretzky… - Annual review of …, 2009 - annualreviews.org
This year marks the 25th anniversary of the first Annual Review of Immunology article to
describe features of the T cell antigen receptor (TCR). In celebration of this anniversary, we …
describe features of the T cell antigen receptor (TCR). In celebration of this anniversary, we …
Transcription factors of the NFAT family: regulation and function
A Rao, C Luo, PG Hogan - Annual review of immunology, 1997 - annualreviews.org
▪ Abstract As targets for the immunosuppressive drugs cyclosporin A and FK506,
transcription factors of the NFAT (nuclear factor of activated T cells) family have been the …
transcription factors of the NFAT (nuclear factor of activated T cells) family have been the …
Pan-peptide meta learning for T-cell receptor–antigen binding recognition
The identification of the mechanisms by which T-cell receptors (TCRs) interact with human
antigens provides a crucial opportunity to develop new vaccines, diagnostics and …
antigens provides a crucial opportunity to develop new vaccines, diagnostics and …
Regulatory mechanisms in T cell receptor signalling
The remarkable T cell receptor (TCR) performs essential functions in the initiation of
intracellular signals required for T cell development, repertoire selection and effector …
intracellular signals required for T cell development, repertoire selection and effector …
NK cell receptors
LL Lanier - Annual review of immunology, 1998 - annualreviews.org
▪ Abstract NK cells are regulated by opposing signals from receptors that activate and inhibit
effector function. While positive stimulation may be initiated by an array of co-stimulatory …
effector function. While positive stimulation may be initiated by an array of co-stimulatory …
Glutamine uptake and metabolism are coordinately regulated by ERK/MAPK during T lymphocyte activation
EL Carr, A Kelman, GS Wu, R Gopaul… - The Journal of …, 2010 - journals.aai.org
Activation of a naive T cell is a highly energetic event, which requires a substantial increase
in nutrient metabolism. Upon stimulation, T cells increase in size, rapidly proliferate, and …
in nutrient metabolism. Upon stimulation, T cells increase in size, rapidly proliferate, and …
Zinc and immunity: An essential interrelation
The significance of the essential trace element zinc for immune function has been known for
several decades. Zinc deficiency affects immune cells, resulting in altered host defense …
several decades. Zinc deficiency affects immune cells, resulting in altered host defense …
Jurkat T cells and development of the T-cell receptor signalling paradigm
Twenty years of investigation have yielded a detailed view of the signalling machinery
engaged by T-cell receptors (TCRs). Many of the fundamental insights into TCR signalling …
engaged by T-cell receptors (TCRs). Many of the fundamental insights into TCR signalling …
Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen
ME Ballestas, PA Chatis, KM Kaye - Science, 1999 - science.org
Primary effusion lymphoma (PEL) cells harbor Kaposi's sarcoma–associated herpesvirus
(KSHV) episomes and express a KSHV-encoded latency-associated nuclear antigen …
(KSHV) episomes and express a KSHV-encoded latency-associated nuclear antigen …
Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor
The role of lipid rafts in T cell antigen receptor (TCR) signaling was investigated using
fluorescence microscopy. Lipid rafts labeled with cholera toxin B subunit (CT-B) and cross …
fluorescence microscopy. Lipid rafts labeled with cholera toxin B subunit (CT-B) and cross …