Precision medicine in stroke: towards personalized outcome predictions using artificial intelligence

AK Bonkhoff, C Grefkes - Brain, 2022‏ - academic.oup.com
Stroke ranks among the leading causes for morbidity and mortality worldwide. New and
continuously improving treatment options such as thrombolysis and thrombectomy have …

Effects of physical therapy modalities for motor function, functional recovery, and post-stroke complications in patients with severe stroke: a systematic review update

K Roesner, B Scheffler, M Kaehler… - Systematic …, 2024‏ - Springer
Background Physical therapy interventions play a crucial role in the daily care of patients
recovering from severe stroke. However, the efficacy of these interventions and associated …

Sensitivity to change and responsiveness of the upper extremity Fugl-Meyer assessment in individuals with moderate to severe acute stroke

BP Huynh, JA DiCarlo, I Vora… - … and Neural Repair, 2023‏ - journals.sagepub.com
Background The Fugl-Meyer Assessment-Upper Extremity (FMA-UE) is a widely used
outcome measure for quantifying motor impairment in stroke recovery. Meaningful change …

Arguments for the biological and predictive relevance of the proportional recovery rule

J Goldsmith, T Kitago, AG de la Garza, R Kundert… - Elife, 2022‏ - elifesciences.org
The proportional recovery rule (PRR) posits that most stroke survivors can expect to reduce
a fixed proportion of their motor impairment. As a statistical model, the PRR explicitly relates …

Frontoparietal structural network disconnections correlate with outcome after a severe stroke

L Frontzkowski, F Fehring, BM Frey… - Human Brain …, 2024‏ - Wiley Online Library
Structural disconnectome analyses have provided valuable insights into how a stroke lesion
results in widespread network disturbances and how these relate to deficits, recovery …

The stratified effects of repetitive transcranial magnetic stimulation in upper limb motor impairment recovery after stroke: a meta-analysis

R Li, S Liu, T Li, K Yang, X Wang, W Wang - Frontiers in Neurology, 2024‏ - frontiersin.org
Background The recovery of upper extremity motor impairment after stroke remains a
challenging task. The clinical effectiveness of repetitive transcranial magnetic stimulation …

Charting the Course of Aphasia Recovery: Factors, Trajectories, and Outcomes

MJ Marte, M Russell-Meill, N Carvalho… - Annual Review of …, 2025‏ - annualreviews.org
Aphasia, a neurological condition primarily resulting from stroke, significantly impairs
communication and quality of life. This review focuses on aphasia recovery and emphasizes …

Prediction of post-stroke motor recovery benefits from measures of sub-acute widespread network damages

C Rivier, MG Preti, P Nicolo, D Van De Ville… - Brain …, 2023‏ - academic.oup.com
Following a stroke in regions of the brain responsible for motor activity, patients can lose
their ability to control parts of their body. Over time, some patients recover almost completely …

Dopaminergic mesolimbic structural reserve is positively linked to better outcome after severe stroke

L Asmussen, BM Frey, LK Frontzkowski… - Brain …, 2024‏ - academic.oup.com
The concept of brain reserve capacity has emerged in stroke recovery research in recent
years. Imaging-based biomarkers of brain health have helped to better understand outcome …

Proportional recovery in mice with cortical stroke

A Kalantari, C Hambrock, C Grefkes, GR Fink… - Experimental …, 2025‏ - Elsevier
Abstract The proportional Recovery Rule (PRR) has been frequently used to predict
recovery of lost motor function in acute stroke patients. However, it still needs to be explored …