Mitochondrial dysfunction and excessive inflammatory responses are both sufficient to
induce pathology in age-dependent neurodegenerations. However, emerging evidence …

Glaucoma is one of the leading causes of vision impairment worldwide. In order to further
understand the molecular pathobiology of this disease and to develop better therapies …

Despite high metabolic activity, the retina and optic nerve head lack traditional lymphatic
drainage. We here identified an ocular glymphatic clearance route for fluid and wastes via …

Increased intraocular pressure (IOP) represents a major risk factor for glaucoma, a prevalent
eye disease characterized by death of retinal ganglion cells; lowering IOP is the only proven …

Human pluripotent stem cells have the potential to promote biological studies and
accelerate drug discovery efforts by making possible direct experimentation on a variety of …

Dysregulation of the complement system is implicated in neurodegeneration, including
human and animal glaucoma. Optic nerve and retinal damage in glaucoma is preceded by …

Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a
valuable model system to study the generation and mechanisms modulating conventional …

Glaucoma is a complex and multifactorial disease defined as the loss of retinal ganglion
cells (RGCs) and their axons. Besides an elevated intraocular pressure (IOP), other …

Mitochondrial dysfunction may be an important, if not essential, component of human
glaucoma. Using transcriptomics followed by molecular and neurobiological techniques, we …

Optic neuropathies such as glaucoma are characterized by the degeneration of retinal
ganglion cells (RGCs) and the irreversible loss of vision. In these diseases, focal axon injury …