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Trauma-induced coagulopathy
Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …
Regulation of platelet activation and coagulation and its role in vascular injury and arterial thrombosis
Hemostasis requires the tightly regulated interaction of the coagulation system, platelets,
other blood cells and components of the vessel wall at a site of vascular injury. The …
other blood cells and components of the vessel wall at a site of vascular injury. The …
Multi-omics approaches for revealing the complexity of cardiovascular disease
The development and progression of cardiovascular disease (CVD) can mainly be attributed
to the narrowing of blood vessels caused by atherosclerosis and thrombosis, which induces …
to the narrowing of blood vessels caused by atherosclerosis and thrombosis, which induces …
Fluid mechanics of blood clot formation
Intravascular blood clots form in an environment in which hydrodynamic forces dominate
and in which fluid-mediated transport is the primary means of moving material. The clotting …
and in which fluid-mediated transport is the primary means of moving material. The clotting …
Grow with the flow: a spatial–temporal model of platelet deposition and blood coagulation under flow
The body's response to vascular injury involves two intertwined processes: platelet
aggregation and coagulation. Platelet aggregation is a predominantly physical process …
aggregation and coagulation. Platelet aggregation is a predominantly physical process …
Matrix metalloproteases and PAR1 activation
Cardiovascular diseases, including atherothrombosis, are the leading cause of morbidity
and mortality in the United States, Europe, and the developed world. Matrix …
and mortality in the United States, Europe, and the developed world. Matrix …
[HTML][HTML] Platelet matrix metalloprotease-1 mediates thrombogenesis by activating PAR1 at a cryptic ligand site
Matrix metalloproteases (MMPs) play important roles in normal and pathological remodeling
processes including atherothrombotic disease, inflammation, angiogenesis, and cancer …
processes including atherothrombotic disease, inflammation, angiogenesis, and cancer …
Tissue factor in coagulation: which? where? when?
Tissue factor (TF) is an integral membrane protein, normally separated from the blood by the
vascular endothelium, which plays a key role in the initiation of blood coagulation. With a …
vascular endothelium, which plays a key role in the initiation of blood coagulation. With a …
Systems biology of coagulation initiation: kinetics of thrombin generation in resting and activated human blood
Blood function defines bleeding and clotting risks and dictates approaches for clinical
intervention. Independent of adding exogenous tissue factor (TF), human blood treated in …
intervention. Independent of adding exogenous tissue factor (TF), human blood treated in …
Microfluidics and coagulation biology
The study of blood ex vivo can occur in closed or open systems, with or without flow.
Microfluidic devices, which constrain fluids to a small (typically submillimeter) scale, facilitate …
Microfluidic devices, which constrain fluids to a small (typically submillimeter) scale, facilitate …