Organ allotransplantation has now reached an impassable ceiling inherent to the limited
supply of human donor organs. In the United States, there are currently over 100,000 …

Background Chronic kidney disease (CKD) is a major cause of early death worldwide. By
2030, 14.5 million people will have end‐stage kidney disease (ESKD, or CKD stage 5), yet …

Chronic kidney disease affects an estimated 37 million people in the United States; of
these,> 800,000 have end-stage renal disease requiring chronic dialysis or a kidney …

The future clinical application of animal‐to‐human transplantation (xenotransplantation) is of
importance to society as a whole. Favourable preclinical data relevant to cell, tissue and …

Xenotransplantation holds great promise as a solution to address the critical shortage of
organs, but it raises concerns regarding the potential transmission of porcine viruses to …

Sda, produced by the B4GALNT2 enzyme, has been recognized as an important
xenoantigen for pig-to-nonhuman primate xenotransplantation. However, little is known …

Extracellular matrix (ECM) rich whole organ bio-scaffolds, preserving structural integrity and
essential growth factors, has potential towards regeneration and reconstruction. Women with …

Antibody‐mediated rejection (AMR) is the commonest cause of failure of a pig graft after
transplantation into an immunosuppressed nonhuman primate (NHP). The incidence of …

Background Highly sensitized patients face many barriers to kidney transplantation,
including higher rates of antibody‐mediated rejection after HLA‐incompatible transplant …

Tissue engineering holds great promise for biomedical research and healthcare, offering
alternatives to animal models and enabling tissue regeneration and organ transplantation …