The NLRP3 inflammasome pathway: a review of mechanisms and inhibitors for the treatment of inflammatory diseases

HM Blevins, Y Xu, S Biby, S Zhang - Frontiers in aging neuroscience, 2022 - frontiersin.org
The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …

The role of plant‐derived natural antioxidants in reduction of oxidative stress

B Akbari, N Baghaei‐Yazdi, M Bahmaie… - …, 2022 - Wiley Online Library
Free radicals are a group of damaging molecules produced during the normal metabolism of
cells in the human body. Exposure to ultraviolet radiation, cigarette smoking, and other …

[HTML][HTML] Flavonoids: Their putative neurologic roles, epigenetic changes, and gut microbiota alterations in Parkinson's disease

Y Açar, D Ağagündüz, P De Cicco… - Biomedicine & …, 2023 - Elsevier
Abstract Parkinson's Disease (PD), a neurodegenerative disorder, is characterized by the
degeneration of progressive dopaminergic (DA) neurons in the substantia nigra region of …

Polyphenols—Gut microbiota interrelationship: A transition to a new generation of prebiotics

D Plamada, DC Vodnar - Nutrients, 2021 - mdpi.com
The present review summarizes the studies carried out on this topic in the last five years.
According to the new definitions, among all the compounds included in the group of …

Polyphenols: A concise overview on the chemistry, occurrence, and human health

A Durazzo, M Lucarini, EB Souto, C Cicala… - Phytotherapy …, 2019 - Wiley Online Library
This review gives an updated picture of each class of phenolic compounds and their
properties. The most common classification implies the subdivision of phenolics in two main …

Flavonoids: A treasure house of prospective pharmacological potentials

H Hasnat, SA Shompa, MM Islam, S Alam, FT Richi… - Heliyon, 2024 - cell.com
Flavonoids are organic compounds characterized by a range of phenolic structures, which
are abundantly present in various natural sources such as fruits, vegetables, cereals, bark …

A systematic review on ethnopharmacology, phytochemistry and pharmacological aspects of Thymus vulgaris Linn.

SM Patil, R Ramu, PS Shirahatti, C Shivamallu… - Heliyon, 2021 - cell.com
Thymus vulgaris Linn. is a medicinal and culinary herb from the Southern European region
known for its anti-infective, cardioprotective, gastroprotective, anti-inflammatory, and …

Structural basis for urate recognition and apigenin inhibition of human GLUT9

Z Shen, L Xu, T Wu, H Wang, Q Wang, X Ge… - Nature …, 2024 - nature.com
Urate, the physiological form of uric acid and a potent antioxidant in serum, plays a pivotal
role in scavenging reactive oxygen species. Yet excessive accumulation of urate, known as …

[HTML][HTML] The role of antioxidants in the interplay between oxidative stress and senescence

A Varesi, S Chirumbolo, LIM Campagnoli, E Pierella… - Antioxidants, 2022 - mdpi.com
Cellular senescence is an irreversible state of cell cycle arrest occurring in response to
stressful stimuli, such as telomere attrition, DNA damage, reactive oxygen species, and …

Targeting metabolic diseases: the role of nutraceuticals in modulating oxidative stress and inflammation

A Dama, K Shpati, P Daliu, S Dumur, E Gorica… - Nutrients, 2024 - mdpi.com
The escalating prevalence of metabolic and cardiometabolic disorders, often characterized
by oxidative stress and chronic inflammation, poses significant health challenges globally …