Mycobacterium tuberculosis, the causative agent of tuberculosis, has infected humans for
millennia. M. tuberculosis is well adapted to establish infection, persist in the face of the host …

The advent of COVID-19 and the persistent threat of infectious diseases such as
tuberculosis, malaria, influenza and HIV/AIDS remind us of the marked impact that infections …

A greater understanding of hematopoietic stem cell (HSC) regulation is required for
dissecting protective versus detrimental immunity to pathogens that cause chronic infections …

T lymphocytes (T cells) are divided into two functionally different subgroups the CD4+ T
helper cells (Th) and the CD8+ cytotoxic T lymphocytes (CTL). Adequate CD4 and CD8 T …

Since the vast majority of species solely rely on innate immunity for host defense, it stands to
reason that a critical evolutionary trait like immunological memory evolved in this primitive …

Vaccine development against tuberculosis (TB) is based on the induction of adaptive
immune responses endowed with long-term memory against mycobacterial antigens …

The human-specific gene ARHGAP11B is preferentially expressed in neural progenitors of
fetal human neocortex and increases abundance and proliferation of basal progenitors …

Previously, we developed a 3-dimensional cell culture model of human tuberculosis (TB)
and demonstrated its potential to interrogate the host-pathogen interaction (Tezera et al …

Pathogenic organisms exert a negative impact on host health, revealed by the clinical signs
of infectious diseases. Immunity limits the severity of infectious diseases through resistance …

Immunological priming—in the context of either prior infection or vaccination—elicits
protective responses against subsequent Mycobacterium tuberculosis (Mtb) infection …