Alzheimer's disease is the most common neurodegenerative disorder that can cause
dementia in elderly over 60 years of age. One of the disease hallmarks is oxidative stress …

Delirium is a clinical syndrome occurring in heterogeneous patient populations. It affects 45–
87% of critical care patients and is often associated with adverse outcomes including …

Deterioration of brain capillary flow and architecture is a hallmark of aging and dementia. It
remains unclear how loss of brain pericytes in these conditions contributes to capillary …

Aging is frequently associated with compromised cerebrovasculature and pericytes.
However, we do not know how normal aging differentially impacts vascular structure and …

Accurate identification of brain function is necessary to understand the neurobiology of
cognitive ageing, and thereby promote well-being across the lifespan. A common tool used …

Aging of the vasculature, which is integral to the functioning of literally all human organs,
serves as a fundamental physiological basis for age-related alterations as well as a shared …

Retinal microcirculation shares similar features with cerebral small blood vessels. Thus, the
retina may be considered an accessible 'window'to detect the microvascular damage …

China and the world are facing severe population aging and an increasing burden of age-
related diseases. Aging of the brain causes major age-related brain diseases, such as …

As global life expectancy increases, age-related brain diseases such as stroke and
dementia have become leading causes of death and disability. The aging of the …

Ageing is accompanied by a steady decline in touch sensitivity and acuity. Conversely,
pleasant touch, such as experienced during a caress, is even more pleasant in old age …