Pharmaceutical applications of hot-melt extrusion: part I

MM Crowley, F Zhang, MA Repka… - Drug development …, 2007 - Taylor & Francis
Interest in hot-melt extrusion techniques for pharmaceutical applications is growing rapidly
with well over 100 papers published in the pharmaceutical scientific literature in the last 12 …

The applications of Vitamin E TPGS in drug delivery

Y Guo, J Luo, S Tan, BO Otieno, Z Zhang - European journal of …, 2013 - Elsevier
d-α-Tocopheryl polyethylene glycol 1000 succinate (simply TPGS or Vitamin E TPGS) is
formed by the esterification of Vitamin E succinate with polyethylene glycol 1000. As novel …

Making highly elastic and tough hydrogels from doughs

G Nian, J Kim, X Bao, Z Suo - Advanced Materials, 2022 - Wiley Online Library
A hydrogel is often fabricated from preexisting polymer chains by covalently crosslinking
them into a polymer network. The crosslinks make the hydrogel swell‐resistant but brittle …

A review of hot‐melt extrusion: process technology to pharmaceutical products

M Maniruzzaman, JS Boateng… - International …, 2012 - Wiley Online Library
Over the last three decades industrial adaptability has allowed hot‐melt extrusion (HME) to
gain wide acceptance and has already established its place in the broad spectrum of …

Pharmaceutical applications of hot-melt extrusion: Part II

MA Repka, SK Battu, SB Upadhye… - Drug development …, 2007 - Taylor & Francis
The advent of high through-put screening in the drug discovery process has resulted in
compounds with high lipophilicity and poor solubility. Increasing the solubility of such …

3D printed oral theophylline doses with innovative 'radiator-like'design: Impact of polyethylene oxide (PEO) molecular weight

A Isreb, K Baj, M Wojsz, M Isreb, M Peak… - International journal of …, 2019 - Elsevier
Despite the abundant use of polyethylene oxides (PEOs) and their integration as an
excipient in numerous pharmaceutical products, there have been no previous reports of …

[BOOK][B] Handbook of encapsulation and controlled release

M Mishra - 2015 - books.google.com
Written at a level comprehensible to non-experts, this handbook covers the current state of
encapsulation and controlled released technologies, presenting the fundamental processes …

Accelerated aging: prediction of chemical stability of pharmaceuticals

KC Waterman, RC Adami - International Journal of Pharmaceutics, 2005 - Elsevier
Methods of rapidly and accurately assessing the chemical stability of pharmaceutical
dosage forms are reviewed with respect to the major degradation mechanisms generally …

[HTML][HTML] Hot-melt extrusion in the pharmaceutical industry: toward filing a new drug application

MF Simões, RMA Pinto, S Simões - Drug Discovery Today, 2019 - Elsevier
The pharmaceutical development of amorphous solid dispersions (ASDs) by hot-melt
extrusion (HME) is briefly reviewed. A systematic step-by-step approach is presented, where …

Hot melt extrusion: Highlighting physicochemical factors to be investigated while designing and optimizing a hot melt extrusion process

R Censi, MR Gigliobianco, C Casadidio, P Di Martino - Pharmaceutics, 2018 - mdpi.com
Hot-melt extrusion (HME) is a well-accepted and extensively studied method for preparing
numerous types of drug delivery systems and dosage forms. It offers several advantages: no …