Progress in toxicogenomics to protect human health

MJ Meier, J Harrill, K Johnson, RS Thomas… - Nature Reviews …, 2024 - nature.com
Toxicogenomics measures molecular features, such as transcripts, proteins, metabolites and
epigenomic modifications, to understand and predict the toxicological effects of …

Advance computational tools for multiomics data learning

S Mansoor, S Hamid, TT Tuan, JE Park… - Biotechnology Advances, 2024 - Elsevier
The burgeoning field of bioinformatics has seen a surge in computational tools tailored for
omics data analysis driven by the heterogeneous and high-dimensional nature of omics …

A comprehensive benchmarking of differential splicing tools for RNA-seq analysis at the event level

M Jiang, S Zhang, H Yin, Z Zhuo… - Briefings in …, 2023 - academic.oup.com
RNA alternative splicing, a post-transcriptional stage in eukaryotes, is crucial in cellular
homeostasis and disease processes. Due to the rapid development of the next-generation …

Calculating Apparent pKa Values of Ionizable Lipids in Lipid Nanoparticles

NB Hamilton, S Arns, M Shelley, I Bechis… - Molecular …, 2024 - ACS Publications
Creating new ionizable lipids for use in lipid nanoparticles (LNPs) is an active field of
research. One of the critical properties for selecting suitable ionizable lipids is the apparent p …

Advances in long-read single-cell transcriptomics

P Kumari, M Kaur, K Dindhoria, B Ashford… - Human Genetics, 2024 - Springer
Long-read single-cell transcriptomics (scRNA-Seq) is revolutionizing the way we profile
heterogeneity in disease. Traditional short-read scRNA-Seq methods are limited in their …

[HTML][HTML] Non-coding RNAs: foes or friends for targeting tumor microenvironment

A Szymanowska, C Rodriguez-Aguayo… - Non-coding RNA, 2023 - mdpi.com
Non-coding RNAs (ncRNAs) are a group of molecules critical for cell development and
growth regulation. They are key regulators of important cellular pathways in the tumor …

[HTML][HTML] Advances in the Degradation of Polycyclic Aromatic Hydrocarbons by Yeasts: A Review

F Padilla-Garfias, M Araiza-Villanueva… - …, 2024 - pmc.ncbi.nlm.nih.gov
Polycyclic aromatic hydrocarbons (PAHs) are toxic organic compounds produced during the
incomplete combustion of organic materials and are commonly found in the environment …

Acupuncture Extended the Thrombolysis Window by Suppressing Blood–Brain Barrier Disruption and Regulating Autophagy–Apoptosis Balance after Ischemic Stroke

Z Zhang, T Lu, S Li, R Zhao, H Li, X Zhang, Y Li, Y **a… - Brain Sciences, 2024 - mdpi.com
Background: Ischemic stroke (IS) is one of the leading causes of death and disability
worldwide. The narrow therapeutic window (within 4.5 h) and severe hemorrhagic potential …

Biodegradation of polystyrene and systems biology-based approaches to the development of new biocatalysts for plastic degradation

YB Kim, S Kim, C Park, SJ Yeom - Current Opinion in Systems Biology, 2024 - Elsevier
Plastic waste has become one of the most pressing environmental issues with rapidly
increased their production that also has a severe impact on individual species and …

Wnt3a/GSK3β/β-catenin Signalling Modulates Doxorubicin-associated Memory Deficits in Breast Cancer

W Li, C Gan, S Yu, J Xu, LX Tang, H Cheng - Molecular Neurobiology, 2024 - Springer
Background: Chemobrain is widespread in breast cancer patients receiving chemotherapy.
However, the exact mechanism, especially the associated signalling pathway, is not …