Synaptic memory and CaMKII
RA Nicoll, H Schulman - Physiological reviews, 2023 - journals.physiology.org
Ca2+/calmodulin-dependent protein kinase II (CaMKII) and long-term potentiation (LTP)
were discovered within a decade of each other and have been inextricably intertwined ever …
were discovered within a decade of each other and have been inextricably intertwined ever …
The corticohippocampal circuit, synaptic plasticity, and memory
J Basu, SA Siegelbaum - Cold Spring Harbor …, 2015 - cshperspectives.cshlp.org
Synaptic plasticity serves as a cellular substrate for information storage in the central
nervous system. The entorhinal cortex (EC) and hippocampus are interconnected brain …
nervous system. The entorhinal cortex (EC) and hippocampus are interconnected brain …
Synaptic modifications in cultured hippocampal neurons: dependence on spike timing, synaptic strength, and postsynaptic cell type
G Bi, M Poo - Journal of neuroscience, 1998 - Soc Neuroscience
In cultures of dissociated rat hippocampal neurons, persistent potentiation and depression of
glutamatergic synapses were induced by correlated spiking of presynaptic and postsynaptic …
glutamatergic synapses were induced by correlated spiking of presynaptic and postsynaptic …
[HTML][HTML] Theta burst stimulation of the human motor cortex
It has been 30 years since the discovery that repeated electrical stimulation of neural
pathways can lead to long-term potentiation in hippocampal slices. With its relevance to …
pathways can lead to long-term potentiation in hippocampal slices. With its relevance to …
Natural oligomers of the Alzheimer amyloid-β protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway
Alzheimer's disease (AD) is characterized by decreased synapse density in hippocampus
and neocortex, and synapse loss is the strongest anatomical correlate of the degree of …
and neocortex, and synapse loss is the strongest anatomical correlate of the degree of …
A critical window for cooperation and competition among develo** retinotectal synapses
In the develo** frog visual system, topographic refinement of the retinotectal projection
depends on electrical activity. In vivo whole-cell recording from develo** Xenopus tectal …
depends on electrical activity. In vivo whole-cell recording from develo** Xenopus tectal …
Dendritic excitability and synaptic plasticity
Most synaptic inputs are made onto the dendritic tree. Recent work has shown that dendrites
play an active role in transforming synaptic input into neuronal output and in defining the …
play an active role in transforming synaptic input into neuronal output and in defining the …
NMDA induces long-term synaptic depression and dephosphorylation of the GluR1 subunit of AMPA receptors in hippocampus
Brief bath application of N-methyl-D-aspartate (NMDA) to hippocampal slices produces long-
term synaptic depression (LTD) in CA1 that is (1) sensitive to postnatal age,(2) saturable,(3) …
term synaptic depression (LTD) in CA1 that is (1) sensitive to postnatal age,(2) saturable,(3) …
Alzheimer's disease: synaptic dysfunction and Aβ
Synapse loss is an early and invariant feature of Alzheimer's disease (AD) and there is a
strong correlation between the extent of synapse loss and the severity of dementia …
strong correlation between the extent of synapse loss and the severity of dementia …
Calcium-and activity-dependent synaptic plasticity
RS Zucker - Current opinion in neurobiology, 1999 - Elsevier
Calcium ions play crucial signaling roles in many forms of activity-dependent synaptic
plasticity. Recent presynaptic [Ca2+] i measurements and manipulation of presynaptic …
plasticity. Recent presynaptic [Ca2+] i measurements and manipulation of presynaptic …