New progress in the pharmacology of protocatechuic acid: A compound ingested in daily foods and herbs frequently and heavily

J Song, Y He, C Luo, B Feng, F Ran, H Xu, Z Ci… - Pharmacological …, 2020 - Elsevier
Protocatechuic acid is a natural phenolic acid, which widely exists in our daily diet and
herbs. It is also one of the main metabolites of complex polyphenols, such as anthocyanins …

Antioxidant effects of protocatechuic acid and protocatechuic aldehyde: old wine in a new bottle

S Zhang, Z Gai, T Gui, J Chen… - Evidence‐Based …, 2021 - Wiley Online Library
Phenolic compounds are naturally present as secondary metabolites in plant‐based
sources such as fruits, vegetables, and spices. They have received considerable attention …

Protocatechuic acid mitigates cadmium-induced neurotoxicity in rats: Role of oxidative stress, inflammation and apoptosis

EM Al Olayan, AS Aloufi, OD AlAmri, H Ola… - Science of the total …, 2020 - Elsevier
Environmental and occupational exposure to heavy metals, including cadmium (Cd), is
associated with extremely adverse impacts to living systems. Antioxidant agents are …

Luteolin attenuates doxorubicin-induced derangements of liver and kidney by reducing oxidative and inflammatory stress to suppress apoptosis

SE Owumi, DO Lewu, UO Arunsi… - Human & experimental …, 2021 - journals.sagepub.com
Doxorubicin is an effective anti-neoplastic agent; the reported toxicities of DOX limit its use.
Luteolin is a polyphenolic phytochemical that exhibits beneficial biological effects via …

Protocatechuic acid abrogates oxidative insults, inflammation, and apoptosis in liver and kidney associated with monosodium glutamate intoxication in rats

RB Kassab, A Theyab, AO Al-Ghamdy… - … Science and Pollution …, 2022 - Springer
Monosodium glutamate (MSG), a commonly used flavor enhancer, has been reported to
induce hepatic and renal dysfunctions. In this study, the palliative role of protocatechuic acid …

Reductive stress‐induced mitochondrial dysfunction and cardiomyopathy

WX Ma, CY Li, R Tao, XP Wang… - Oxidative medicine and …, 2020 - Wiley Online Library
The goal of this review was to summarize reported studies focusing on cellular reductive
stress‐induced mitochondrial dysfunction, cardiomyopathy, dithiothreitol‐(DTT‐) induced …

Potential use of edaravone to reduce specific side effects of chemo-, radio-and immuno-therapy of cancers

C Bailly - International Immunopharmacology, 2019 - Elsevier
The drug edaravone (EDA) is prescribed for the treatment of patients with amyotrophic
lateral sclerosis or after an acute cerebral infarction. This synthetic pyrazolone derivative is a …

Co-administration of Luteolin mitigated toxicity in rats' lungs associated with doxorubicin treatment

SE Owumi, SO Nwozo, UO Arunsi, AK Oyelere… - Toxicology and applied …, 2021 - Elsevier
Doxorubicin (DOX), is a drug against lung malignancies with undesirable side effect
including oxidative, inflammatory and apoptotic effects. Luteolin (LUT), present in fruits and …

[HTML][HTML] Ethanol Extract of Maclura tricuspidata Fruit Protects SH-SY5Y Neuroblastoma Cells against H2O2-Induced Oxidative Damage via Inhibiting MAPK and NF …

W Tian, S Heo, DW Kim, IS Kim, D Ahn, HJ Tae… - International Journal of …, 2021 - mdpi.com
Free radical generation and oxidative stress push forward an immense influence on the
pathogenesis of neurodegenerative diseases such as Alzheimer's disease and Parkinson's …

Biodegradable porous polymeric drug with pH-stimuli-responsive delivery capacity for combined cancer therapy

H Lou, H Fang, T Wang, D Wang, Q Han… - ACS Applied Polymer …, 2021 - ACS Publications
Polymeric drugs are a class of drug in which the polymer itself acts as the active ingredient
of the drug. Here, we constructed a biodegradable covalent organic porous polymer (COP) …