Chemical design and synthesis of functionalized probes for imaging and treating tumor hypoxia

J Liu, W Bu, J Shi - Chemical reviews, 2017 - ACS Publications
Hypoxia development in tumor is closely associated with its increased aggressiveness and
strong resistance to therapy, leading to the poor prognosis in several cancer types …

The clinical importance of assessing tumor hypoxia: relationship of tumor hypoxia to prognosis and therapeutic opportunities

JC Walsh, A Lebedev, E Aten, K Madsen… - Antioxidants & redox …, 2014 - liebertpub.com
Tumor hypoxia is a well-established biological phenomenon that affects the curability of
solid tumors, regardless of treatment modality. Especially for head and neck cancer patients …

Imaging hypoxia to improve radiotherapy outcome

MR Horsman, LS Mortensen, JB Petersen… - Nature reviews Clinical …, 2012 - nature.com
Reduced oxygen levels (hypoxia) is one of the most important factors influencing clinical
outcome after radiotherapy. This is primarily because hypoxic cells are resistant to radiation …

Synthesis of 11C, 18F, 15O, and 13N Radiolabels for Positron Emission Tomography

PW Miller, NJ Long, R Vilar… - Angewandte Chemie …, 2008 - Wiley Online Library
Positron emission tomography (PET) is a powerful and rapidly develo** area of molecular
imaging that is used to study and visualize human physiology by the detection of positron …

The role of oxidative stress and hypoxia in renal disease

T Honda, Y Hirakawa… - Kidney research and …, 2019 - pmc.ncbi.nlm.nih.gov
Oxygen is required to sustain aerobic organisms. Reactive oxygen species (ROS) are
constantly released during mitochondrial oxygen consumption for energy production. Any …

[HTML][HTML] FAZA PET/CT hypoxia imaging in patients with squamous cell carcinoma of the head and neck treated with radiotherapy: results from the DAHANCA 24 trial

LS Mortensen, J Johansen, J Kallehauge… - Radiotherapy and …, 2012 - Elsevier
PURPOSE: Hypoxia is a cause of resistance to radiotherapy, especially in patients with
head and neck squamous cell carcinoma (HNSCC). The purpose of this study was to …

Molecular imaging of hypoxia

KA Krohn, JM Link, RP Mason - Journal of Nuclear Medicine, 2008 - jnm.snmjournals.org
Hypoxia, a condition of insufficient O 2 to support metabolism, occurs when the vascular
supply is interrupted, as in stroke or myocardial infarction, or when a tumor outgrows its …

Overview of image-guided radiation therapy

L **ng, B Thorndyke, E Schreibmann, Y Yang, TF Li… - Medical …, 2006 - Elsevier
Radiation therapy has gone through a series of revolutions in the last few decades and it is
now possible to produce highly conformal radiation dose distribution by using techniques …

PET radiopharmaceuticals for imaging of tumor hypoxia: a review of the evidence

E Lopci, I Grassi, A Chiti, C Nanni… - American journal of …, 2014 - pmc.ncbi.nlm.nih.gov
Hypoxia is a pathological condition arising in living tissues when oxygen supply does not
adequately cover the cellular metabolic demand. Detection of this phenomenon in tumors is …

[HTML][HTML] The meaning, measurement and modification of hypoxia in the laboratory and the clinic

EM Hammond, MC Asselin, D Forster, JPB O'Connor… - Clinical oncology, 2014 - Elsevier
Hypoxia was identified as a microenvironmental component of solid tumours over 60 years
ago and was immediately recognised as a potential barrier to therapy through the reliance of …