Applications of multi‐omics analysis in human diseases

C Chen, J Wang, D Pan, X Wang, Y Xu, J Yan… - MedComm, 2023 - Wiley Online Library
Multi‐omics usually refers to the crossover application of multiple high‐throughput screening
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …

Unlocking hidden potential: advancements, approaches, and obstacles in repurposing drugs for cancer therapy

FR Weth, GB Hoggarth, AF Weth, E Paterson… - British journal of …, 2024 - nature.com
High rates of failure, exorbitant costs, and the sluggish pace of new drug discovery and
development have led to a growing interest in repurposing “old” drugs to treat both common …

Building a knowledge graph to enable precision medicine

P Chandak, K Huang, M Zitnik - Scientific Data, 2023 - nature.com
Develo** personalized diagnostic strategies and targeted treatments requires a deep
understanding of disease biology and the ability to dissect the relationship between …

Graph neural networks: foundation, frontiers and applications

L Wu, P Cui, J Pei, L Zhao, X Guo - … of the 28th ACM SIGKDD conference …, 2022 - dl.acm.org
The field of graph neural networks (GNNs) has seen rapid and incredible strides over the
recent years. Graph neural networks, also known as deep learning on graphs, graph …

Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course

X Zhou, R Baumann, X Gao, M Mendoza, S Singh… - Cell, 2022 - cell.com
Changes in gut microbiota have been associated with several diseases. Here, the
International Multiple Sclerosis Microbiome Study (iMSMS) studied the gut microbiome of …

A knowledge graph to interpret clinical proteomics data

A Santos, AR Colaço, AB Nielsen, L Niu… - Nature …, 2022 - nature.com
Implementing precision medicine hinges on the integration of omics data, such as
proteomics, into the clinical decision-making process, but the quantity and diversity of …

A survey of knowledge graph reasoning on graph types: Static, dynamic, and multi-modal

K Liang, L Meng, M Liu, Y Liu, W Tu… - … on Pattern Analysis …, 2024 - ieeexplore.ieee.org
Knowledge graph reasoning (KGR), aiming to deduce new facts from existing facts based on
mined logic rules underlying knowledge graphs (KGs), has become a fast-growing research …

Biomedical knowledge graph learning for drug repurposing by extending guilt-by-association to multiple layers

D Bang, S Lim, S Lee, S Kim - Nature Communications, 2023 - nature.com
Computational drug repurposing aims to identify new indications for existing drugs by
utilizing high-throughput data, often in the form of biomedical knowledge graphs. However …

A unified drug–target interaction prediction framework based on knowledge graph and recommendation system

Q Ye, CY Hsieh, Z Yang, Y Kang, J Chen, D Cao… - Nature …, 2021 - nature.com
Prediction of drug-target interactions (DTI) plays a vital role in drug development in various
areas, such as virtual screening, drug repurposing and identification of potential drug side …

Toward better drug discovery with knowledge graph

X Zeng, X Tu, Y Liu, X Fu, Y Su - Current opinion in structural biology, 2022 - Elsevier
Drug discovery is the process of new drug identification. This process is driven by the
increasing data from existing chemical libraries and data banks. The knowledge graph is …