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Applications of multi‐omics analysis in human diseases
Multi‐omics usually refers to the crossover application of multiple high‐throughput screening
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …
Unlocking hidden potential: advancements, approaches, and obstacles in repurposing drugs for cancer therapy
FR Weth, GB Hoggarth, AF Weth, E Paterson… - British journal of …, 2024 - nature.com
High rates of failure, exorbitant costs, and the sluggish pace of new drug discovery and
development have led to a growing interest in repurposing “old” drugs to treat both common …
development have led to a growing interest in repurposing “old” drugs to treat both common …
Building a knowledge graph to enable precision medicine
Develo** personalized diagnostic strategies and targeted treatments requires a deep
understanding of disease biology and the ability to dissect the relationship between …
understanding of disease biology and the ability to dissect the relationship between …
Graph neural networks: foundation, frontiers and applications
The field of graph neural networks (GNNs) has seen rapid and incredible strides over the
recent years. Graph neural networks, also known as deep learning on graphs, graph …
recent years. Graph neural networks, also known as deep learning on graphs, graph …
Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course
X Zhou, R Baumann, X Gao, M Mendoza, S Singh… - Cell, 2022 - cell.com
Changes in gut microbiota have been associated with several diseases. Here, the
International Multiple Sclerosis Microbiome Study (iMSMS) studied the gut microbiome of …
International Multiple Sclerosis Microbiome Study (iMSMS) studied the gut microbiome of …
A knowledge graph to interpret clinical proteomics data
Implementing precision medicine hinges on the integration of omics data, such as
proteomics, into the clinical decision-making process, but the quantity and diversity of …
proteomics, into the clinical decision-making process, but the quantity and diversity of …
A survey of knowledge graph reasoning on graph types: Static, dynamic, and multi-modal
Knowledge graph reasoning (KGR), aiming to deduce new facts from existing facts based on
mined logic rules underlying knowledge graphs (KGs), has become a fast-growing research …
mined logic rules underlying knowledge graphs (KGs), has become a fast-growing research …
Biomedical knowledge graph learning for drug repurposing by extending guilt-by-association to multiple layers
Computational drug repurposing aims to identify new indications for existing drugs by
utilizing high-throughput data, often in the form of biomedical knowledge graphs. However …
utilizing high-throughput data, often in the form of biomedical knowledge graphs. However …
A unified drug–target interaction prediction framework based on knowledge graph and recommendation system
Prediction of drug-target interactions (DTI) plays a vital role in drug development in various
areas, such as virtual screening, drug repurposing and identification of potential drug side …
areas, such as virtual screening, drug repurposing and identification of potential drug side …
Toward better drug discovery with knowledge graph
Drug discovery is the process of new drug identification. This process is driven by the
increasing data from existing chemical libraries and data banks. The knowledge graph is …
increasing data from existing chemical libraries and data banks. The knowledge graph is …