DNA adducting drugs, including alkylating agents and platinum-containing drugs, are
prominent in cancer chemotherapy. Their mechanisms of action involve direct interaction …

This tutorial review highlights key principles underpinning the design of selected
metallodrugs to target specific biological macromolecules (DNA and proteins). The review …

Interstrand DNA–DNA cross-links are highly toxic lesions that are important in medicinal
chemistry, toxicology, and endogenous biology. In current models of replication-dependent …

Interstrand DNA-DNA cross-links (ICLs) are generated by endogenous processes, drugs,
and environmental toxins. Understanding the cellular pathways by which various ICLs are …

The combination of doxorubicin (Adriamycin) and cyclophosphamide, referred to as AC
chemotherapy, is commonly used for the clinical treatment of breast and other cancers. Both …

The experiments described here examined the effects of reaction conditions, various
additives, and local sequence on the formation and stability interstrand cross-links (ICLs) …

Nitrogen mustards, a family of DNA alkylating agents, marked the start of cancer
pharmacotherapy. While traditionally characterized by their dose-limiting toxic effects …

Abasic (AP) sites are one of the most common forms of DNA damage. The deoxyribose ring
of AP sites undergoes anomerization between α and β configurations, via an electrophilic …

DNA–DNA crosslinks, especially interstrand crosslinks (ICLs), cause cytotoxicity via blocking
replication and transcription. Most measurements of ICLs lack sensitivity and structural …

New Strategies Targeting Cancer Metabolism: Anticancer Drugs, Synthetic Analogues and
Antitumor Agents presents up-to-date synthetic strategies for three categories of …