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[HTML][HTML] Pharmacological treatments for cocaine craving: what is the way forward? A systematic review
Background: cocaine craving is a core feature of cocaine use disorder and remains a critical
challenge for abstinence and relapse prevention. This review summarizes the anti-craving …
challenge for abstinence and relapse prevention. This review summarizes the anti-craving …
A randomized placebo-controlled trial of targeted prefrontal cortex modulation with bilateral tDCS in patients with crack-cocaine dependence
Background: Transcranial direct current stimulation over the dorsolateral prefrontal cortex
has been shown to be clinically useful in the treatment of drug addiction. Methods: We …
has been shown to be clinically useful in the treatment of drug addiction. Methods: We …
A threshold model for opposing actions of acetylcholine on reward behavior: molecular mechanisms and implications for treatment of substance abuse disorders
The cholinergic system plays important roles in both learning and addiction. Medications
that modify cholinergic tone can have pronounced effects on behaviors reinforced by natural …
that modify cholinergic tone can have pronounced effects on behaviors reinforced by natural …
Anti‐Parkinson Drug Biperiden Inhibits Enzyme Acetylcholinesterase
A Kostelnik, A Cegan… - BioMed research …, 2017 - Wiley Online Library
Biperiden is a drug used in Parkinson disease treatment and it serves also as an
antiseizures compound in organophosphates poisoning. It acts as antagonist of muscarinic …
antiseizures compound in organophosphates poisoning. It acts as antagonist of muscarinic …
Exploring the efficacy of cholinergic agents for the treatment of psychostimulant use disorder: a systematic review
Rationale No drugs are currently validated to treat psychostimulant use disorder (PUD).
Pathophysiological studies consistently highlight the contribution of cholinergic mechanisms …
Pathophysiological studies consistently highlight the contribution of cholinergic mechanisms …
Preliminary investigation of the administration of biperiden to reduce relapses in individuals with cocaine/crack user disorder: A randomized controlled clinical trial
Background Several studies have demonstrated that ACh modulates the dopaminergic
circuit in the nucleus accumbens, and its blockade appears to be associated with the …
circuit in the nucleus accumbens, and its blockade appears to be associated with the …
Safety and preliminary efficacy of the acetylcholinesterase inhibitor huperzine a as a treatment for cocaine use disorder
Background: Cholinergic transmission is altered by drugs of abuse and contributes to
psychostimulant reinforcement. In particular, acetylcholinesterase inhibitors, like huperzine …
psychostimulant reinforcement. In particular, acetylcholinesterase inhibitors, like huperzine …
Novel pharmacological agents for the treatment of cocaine use disorder
Abstract Purpose of Review This narrative review aims to summarize the literature on novel
pharmacological agents with potential for the treatment of cocaine use disorder. Recent …
pharmacological agents with potential for the treatment of cocaine use disorder. Recent …
Biperiden reverses the increase in 50-kHz ultrasonic vocalizations but not the increase in locomotor activity induced by cocaine
Cocaine use disorder (CUD) is a worldwide public health problem, associated with severe
psychosocial and economic impacts. Currently, no FDA-approved treatment is available for …
psychosocial and economic impacts. Currently, no FDA-approved treatment is available for …
Spending trends on neuropsychiatric drugs in Minas Gerais, Brazil: is the offer of anti-parkinson drugs increasing?
LMS Carvalho, JC Alves, TCB Luz - Ciência & Saúde Coletiva, 2021 - SciELO Brasil
Neuropsychiatric drugs are used for a wide variety of neurological and psychiatric
conditions. This article aims to analyze the trend and determinants of public expenditure of …
conditions. This article aims to analyze the trend and determinants of public expenditure of …