Polymeric nanoparticles for drug delivery
The recent emergence of nanomedicine has revolutionized the therapeutic landscape and
necessitated the creation of more sophisticated drug delivery systems. Polymeric …
necessitated the creation of more sophisticated drug delivery systems. Polymeric …
The cGAS–STING pathway and cancer
The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway has
emerged as a critical innate immune pathway that, following engagement by DNA, promotes …
emerged as a critical innate immune pathway that, following engagement by DNA, promotes …
Exploiting innate immunity for cancer immunotherapy
Immunotherapies have revolutionized the treatment paradigms of various types of cancers.
However, most of these immunomodulatory strategies focus on harnessing adaptive …
However, most of these immunomodulatory strategies focus on harnessing adaptive …
Responsive biomaterials: optimizing control of cancer immunotherapy
Immunotherapy has emerged as an eminent and effective modality in the treatment of
cancer. However, current cancer immunotherapies lack spatial and temporal control …
cancer. However, current cancer immunotherapies lack spatial and temporal control …
Amplifying STING activation by cyclic dinucleotide–manganese particles for local and systemic cancer metalloimmunotherapy
Nutritional metal ions play critical roles in many important immune processes. Hence, the
effective modulation of metal ions may open up new forms of immunotherapy, termed as …
effective modulation of metal ions may open up new forms of immunotherapy, termed as …
STING agonist delivery by tumour-penetrating PEG-lipid nanodiscs primes robust anticancer immunity
Activation of the innate immune STimulator of INterferon Genes (STING) pathway potentiates
antitumour immunity, but systemic delivery of STING agonists to tumours is challenging. We …
antitumour immunity, but systemic delivery of STING agonists to tumours is challenging. We …
Chemically programmed STING-activating nano-liposomal vesicles improve anticancer immunity
The often immune-suppressive tumor microenvironment (TME) may hinder immune evasion
and response to checkpoint blockade therapies. Pharmacological activation of the STING …
and response to checkpoint blockade therapies. Pharmacological activation of the STING …
A bimetallic nanoplatform for STING activation and CRISPR/Cas mediated depletion of the methionine transporter in cancer cells restores anti-tumor immune …
Lack of sufficient cytotoxic T lymphocytes (CD8+ T cells) infiltration and dysfunctional state of
CD8+ T cells are considered enormous obstacles to antitumor immunity. Herein, we …
CD8+ T cells are considered enormous obstacles to antitumor immunity. Herein, we …
Tumor‐microenvironment‐responsive nanomedicine for enhanced cancer immunotherapy
The past decades have witnessed great progress in cancer immunotherapy, which has
profoundly revolutionized oncology, whereas low patient response rates and potential …
profoundly revolutionized oncology, whereas low patient response rates and potential …
Investigation of the enhanced antitumour potency of STING agonist after conjugation to polymer nanoparticles
Intravenously administered cyclic dinucleotides and other STING agonists are hampered by
low cellular uptake and poor circulatory half-life. Here we report the covalent conjugation of …
low cellular uptake and poor circulatory half-life. Here we report the covalent conjugation of …