Methods and applications of in silico aptamer design and modeling
AA Buglak, AV Samokhvalov, AV Zherdev… - International journal of …, 2020 - mdpi.com
Aptamers are nucleic acid analogues of antibodies with high affinity to different targets, such
as cells, viruses, proteins, inorganic materials, and coenzymes. Empirical approaches allow …
as cells, viruses, proteins, inorganic materials, and coenzymes. Empirical approaches allow …
Systematic evolution of ligands by exponential enrichment technologies and aptamer-based applications: Recent progress and challenges in precision medicine of …
Y Xu, X Jiang, Y Zhou, M Ma, M Wang… - … in Bioengineering and …, 2021 - frontiersin.org
Infectious diseases are considered as a pressing challenge to global public health. Accurate
and rapid diagnostics tools for early recognition of the pathogen, as well as individualized …
and rapid diagnostics tools for early recognition of the pathogen, as well as individualized …
Oligonucleotide aptamers: promising and powerful diagnostic and therapeutic tools for infectious diseases
Q Pan, F Luo, M Liu, XL Zhang - Journal of Infection, 2018 - Elsevier
The entire human population is at risk of infectious diseases worldwide. Thus far, the
diagnosis and treatment of human infectious diseases at the molecular and nanoscale …
diagnosis and treatment of human infectious diseases at the molecular and nanoscale …
Aptamers in HIV research diagnosis and therapy
Aptamers are high affinity single-stranded nucleic acid or protein ligands which exhibit
specificity and avidity comparable to, or exceeding that of antibodies and can be generated …
specificity and avidity comparable to, or exceeding that of antibodies and can be generated …
Binding interface and impact on protease cleavage for an RNA aptamer to HIV-1 reverse transcriptase
RNA aptamers that bind HIV-1 reverse transcriptase (RT) inhibit RT in enzymatic and viral
replication assays. Some aptamers inhibit RT from only a few viral clades, while others show …
replication assays. Some aptamers inhibit RT from only a few viral clades, while others show …
In-silico selection of aptamer: A review on the revolutionary approach to understand the aptamer design and interaction through computational chemistry
Aptamers are oligonucleotides and peptides with short and medium length around 15-100
nucleotides or amino acids and a molecule of interests due to its specific binding affinities to …
nucleotides or amino acids and a molecule of interests due to its specific binding affinities to …
Effect of PDGF-B aptamer on PDGFRβ/PDGF-B interaction: molecular dynamics study
Abstract PDGFRβ/PDGF-B interaction plays a role in angiogenesis, and is mandatory in
wound healing and cancer treatment. It has been reported that the PDGF-B aptamer was …
wound healing and cancer treatment. It has been reported that the PDGF-B aptamer was …
Prediction of aptamer affinity using an artificial intelligence approach
Aptamers are oligonucleotide sequences that can connect to particular target molecules,
similar to monoclonal antibodies. They can be chosen by systematic evolution of ligands by …
similar to monoclonal antibodies. They can be chosen by systematic evolution of ligands by …
[HTML][HTML] The neutralisation and inhibitory effects of new tRNA-mimetic aptamer against cytotoxin-induced cytotoxicity in human skin keratinocytes
Cytotoxin (CTX) is the major venom toxin in cobra venom, accounting for the dermonecrosis
in cobra envenomed patients. Conventional antibody-based antivenoms have limited …
in cobra envenomed patients. Conventional antibody-based antivenoms have limited …
Computationally Designed Anti-LuxP DNA Aptamer Suppressed Flagellar Assembly- and Quorum Sensing-Related Gene Expression in Vibrio parahaemolyticus
Simple Summary Infectious diseases are among the problems facing the global aquaculture
industry, particularly Vibriosis, a bacterial infection caused by the Vibrio species. In shrimp …
industry, particularly Vibriosis, a bacterial infection caused by the Vibrio species. In shrimp …