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Drug tolerant persister cell plasticity in cancer: A revolutionary strategy for more effective anticancer therapies
J He, Z Qiu, J Fan, X **, germline and somatic cytogenetic and genetic …
A new genomic framework to categorize pediatric acute myeloid leukemia
Recent studies on pediatric acute myeloid leukemia (pAML) have revealed pediatric-specific
driver alterations, many of which are underrepresented in the current classification schemas …
driver alterations, many of which are underrepresented in the current classification schemas …
Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage-Ambiguous Stem Cell Leukemia
Lineage-ambiguous leukemias are high-risk malignancies of poorly understood genetic
basis. Here, we describe a distinct subgroup of acute leukemia with expression of myeloid, T …
basis. Here, we describe a distinct subgroup of acute leukemia with expression of myeloid, T …
Phase separation mediates NUP98 fusion oncoprotein leukemic transformation
NUP98 fusion oncoproteins (FO) are drivers in pediatric leukemias and many transform
hematopoietic cells. Most NUP98 FOs harbor an intrinsically disordered region from NUP98 …
hematopoietic cells. Most NUP98 FOs harbor an intrinsically disordered region from NUP98 …
The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML
Translocations involving the NUP98 gene produce NUP98-fusion proteins and are
associated with a poor prognosis in acute myeloid leukemia (AML). MLL1 is a molecular …
associated with a poor prognosis in acute myeloid leukemia (AML). MLL1 is a molecular …
[HTML][HTML] A longitudinal single-cell atlas of treatment response in pediatric AML
Pediatric acute myeloid leukemia (pAML) is characterized by heterogeneous cellular
composition, driver alterations and prognosis. Characterization of this heterogeneity and …
composition, driver alterations and prognosis. Characterization of this heterogeneity and …
Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia
The genetics of relapsed pediatric acute myeloid leukemia (AML) has yet to be
comprehensively defined. Here, we present the spectrum of genomic alterations in 136 …
comprehensively defined. Here, we present the spectrum of genomic alterations in 136 …
Exploration of the use of natural compounds in combination with chemotherapy drugs for tumor treatment
J Wu, Y Li, Q He, X Yang - Molecules, 2023 - mdpi.com
Currently, chemotherapy is the main treatment for tumors, but there are still problems such
as unsatisfactory chemotherapy results, susceptibility to drug resistance, and serious …
as unsatisfactory chemotherapy results, susceptibility to drug resistance, and serious …
Phase separations in oncogenesis, tumor progressions and metastasis: a glance from hallmarks of cancer
LW Zheng, CC Liu, KD Yu - Journal of Hematology & Oncology, 2023 - Springer
Liquid–liquid phase separation (LLPS) is a novel principle for interpreting precise
spatiotemporal coordination in living cells through biomolecular condensate (BMC) …
spatiotemporal coordination in living cells through biomolecular condensate (BMC) …