Indoles—A promising scaffold for drug development

TV Sravanthi, SL Manju - European Journal of Pharmaceutical Sciences, 2016 - Elsevier
Generally, heterocycles occupy a prominent place in chemistry due to their wide range of
applications in the fields of drug design, photochemistry, agrochemicals, dyes and so on …

Nitrogen-containing heterocycles as anticancer agents: An overview

DK Lang, R Kaur, R Arora, B Saini… - Anti-Cancer Agents in …, 2020 - ingentaconnect.com
Background: Cancer is spreading all over the world, and it is becoming the leading cause of
major deaths. Today's most difficult task for every researcher is to invent a new drug that can …

Biomedical importance of indoles

NK Kaushik, N Kaushik, P Attri, N Kumar, CH Kim… - Molecules, 2013 - mdpi.com
The indole nucleus is an important element of many natural and synthetic molecules with
significant biological activity. This review covers some of the relevant and recent …

Indole in the target-based design of anticancer agents: A versatile scaffold with diverse mechanisms

S Dadashpour, S Emami - European journal of medicinal chemistry, 2018 - Elsevier
The indole scaffold is one of the most widespread heterocycles in the naturally occurring
and synthetic bioactive compounds including anticancer agents. Due to its biodiversity and …

Anti-cancer nitrogen-containing heterocyclic compounds

Z Hosseinzadeh, A Ramazani… - Current Organic …, 2018 - benthamdirect.com
Cancer is one of the leading causes of death worldwide. Mutation of the cell regulates genes
and protein causing cancer. Surgery, radiotherapy, and the use of anticancer agents are the …

Synthesis, biological evaluation, and molecular docking of novel azolylhydrazonothiazoles as potential anticancer agents

JY Al-Humaidi, SM Gomha, SM Riyadh, MS Ibrahim… - ACS …, 2023 - ACS Publications
A novel set of thiazolylhydrazonothiazoles bearing an indole moiety were synthesized by
subjection reactions of carbothioamide derivative and hydrazonoyl chlorides (or α …

Mechanochemical synthesis and molecular docking studies of new azines bearing indole as anticancer agents

MS Ibrahim, B Farag, J Y. Al-Humaidi, MEA Zaki… - Molecules, 2023 - mdpi.com
The development of new approaches for the synthesis of new bioactive heterocyclic
derivatives is of the utmost importance for pharmaceutical industry. In this regard, the …

Magnetic cellulose/Ag as a novel eco-friendly nanobiocomposite to catalyze synthesis of chromene-linked nicotinonitriles

A Maleki, H Movahed, P Ravaghi - Carbohydrate polymers, 2017 - Elsevier
In this work, design, preparation and performance of magnetic cellulose/Ag
nanobiocomposite as a recyclable and highly efficient heterogeneous nanocatalyst is …

Novel 3-(pyrazol-4-yl)-2-(1H-indole-3-carbonyl)acrylonitrile derivatives induce intrinsic and extrinsic apoptotic death mediated P53 in HCT116 colon carcinoma

MF Mohamed, NS Ibrahim, AA Saddiq… - Scientific Reports, 2023 - nature.com
A novel series of α-cyano indolylchalcones was prepared, and their chemical structures
were confirmed based on the different spectral data. Among them, compound 7f was …

Computer-aided discovery of bis-indole derivatives as multi-target drugs against cancer and bacterial infections: DFT, docking, virtual screening, and molecular …

PSS Gupta, HR Bhat, S Biswal, MK Rana - Journal of Molecular Liquids, 2020 - Elsevier
Recently, more complex diseases of seemingly incurable pathology have demonstrated the
need for potent and multi-target drugs. Specific to many cancers and bacterial diseases …