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Specification and epigenetic programming of the human germ line
Primordial germ cells (PGCs), the precursors of sperm and eggs, are established in
perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a …
perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a …
Ground rules of the pluripotency gene regulatory network
Pluripotency is a state that exists transiently in the early embryo and, remarkably, can be
recapitulated in vitro by deriving embryonic stem cells or by reprogramming somatic cells to …
recapitulated in vitro by deriving embryonic stem cells or by reprogramming somatic cells to …
Failure of human rhombic lip differentiation underlies medulloblastoma formation
Medulloblastoma (MB) comprises a group of heterogeneous paediatric embryonal
neoplasms of the hindbrain with strong links to early development of the hindbrain …
neoplasms of the hindbrain with strong links to early development of the hindbrain …
CRISPR and biochemical screens identify MAZ as a cofactor in CTCF-mediated insulation at Hox clusters
CCCTC-binding factor (CTCF) is critical to three-dimensional genome organization. Upon
differentiation, CTCF insulates active and repressed genes within Hox gene clusters. We …
differentiation, CTCF insulates active and repressed genes within Hox gene clusters. We …
Pioneer and PRDM transcription factors coordinate bivalent epigenetic states to safeguard cell fate
Pioneer transcription factors (TFs) regulate cell fate by establishing transcriptionally primed
and active states. However, cell fate control requires the coordination of both lineage …
and active states. However, cell fate control requires the coordination of both lineage …
Sequential enhancer state remodelling defines human germline competence and specification
Germline–soma segregation is a fundamental event during mammalian embryonic
development. Here we establish the epigenetic principles of human primordial germ cell …
development. Here we establish the epigenetic principles of human primordial germ cell …
Ovarian life cycle
The ovary is a dynamic organ that undergoes some of the most dramatic changes in
structure and function of any adult human tissue. The follicles are the major endocrine and …
structure and function of any adult human tissue. The follicles are the major endocrine and …
[HTML][HTML] Expanding the circuitry of pluripotency by selective isolation of chromatin-associated proteins
Maintenance of pluripotency is regulated by a network of transcription factors coordinated by
Oct4, Sox2, and Nanog (OSN), yet a systematic investigation of the composition and …
Oct4, Sox2, and Nanog (OSN), yet a systematic investigation of the composition and …
[HTML][HTML] Distal and proximal cis-regulatory elements sense X chromosome dosage and developmental state at the **st locus
Developmental genes such as **st, which initiates X chromosome inactivation, are
controlled by complex cis-regulatory landscapes, which decode multiple signals to establish …
controlled by complex cis-regulatory landscapes, which decode multiple signals to establish …
Dppa2 and Dppa4 counteract de novo methylation to establish a permissive epigenome for development
Early mammalian development entails genome-wide epigenome remodeling, including
DNA methylation erasure and reacquisition, which facilitates developmental competence. To …
DNA methylation erasure and reacquisition, which facilitates developmental competence. To …