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Circulating tumor cells: biology and clinical significance
D Lin, L Shen, M Luo, K Zhang, J Li, Q Yang… - Signal transduction and …, 2021 - nature.com
Circulating tumor cells (CTCs) are tumor cells that have sloughed off the primary tumor and
extravasate into and circulate in the blood. Understanding of the metastatic cascade of CTCs …
extravasate into and circulate in the blood. Understanding of the metastatic cascade of CTCs …
Radiotherapy combined with immunotherapy: the dawn of cancer treatment
Radiotherapy (RT) is delivered for purposes of local control, but can also exert systemic
effect on remote and non-irradiated tumor deposits, which is called abscopal effect. The view …
effect on remote and non-irradiated tumor deposits, which is called abscopal effect. The view …
Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer
K Li, H Shi, B Zhang, X Ou, Q Ma, Y Chen… - Signal transduction and …, 2021 - nature.com
Myeloid-derived suppressor cells (MDSCs) are a heterogenic population of immature
myeloid cells with immunosuppressive effects, which undergo massive expansion during …
myeloid cells with immunosuppressive effects, which undergo massive expansion during …
Enhancing immunotherapy response in melanoma: myeloid-derived suppressor cells as a therapeutic target
Despite the remarkable success of immune checkpoint inhibitors (ICIs) in melanoma
treatment, resistance to them remains a substantial clinical challenge. Myeloid-derived …
treatment, resistance to them remains a substantial clinical challenge. Myeloid-derived …
Neutrophils in cancer: dual roles through intercellular interactions
Neutrophils, the most abundant immune cells in human blood, play crucial and diverse roles
in tumor development. In the tumor microenvironment (TME), cancer cells regulate the …
in tumor development. In the tumor microenvironment (TME), cancer cells regulate the …
The complexity of immune evasion mechanisms throughout the metastatic cascade
Metastasis, the spread of cancer from a primary site to distant organs, is an important
challenge in oncology. This Review explores the complexities of immune escape …
challenge in oncology. This Review explores the complexities of immune escape …
N1 versus N2 and PMN‐MDSC: a critical appraisal of current concepts on tumor‐associated neutrophils and new directions for human oncology
BB Antuamwine, R Bosnjakovic… - Immunological …, 2023 - Wiley Online Library
Research on tumor‐associated neutrophils (TAN) currently surges because of the well‐
documented strong clinical relevance of tumor‐infiltrating neutrophils. This relevance is …
documented strong clinical relevance of tumor‐infiltrating neutrophils. This relevance is …
Redefining macrophage and neutrophil biology in the metastatic cascade
Tumor cells metastasize to distant organs through a complex series of events that are driven
by tumor intrinsic and extrinsic factors. In particular, non-malignant stromal cells, including …
by tumor intrinsic and extrinsic factors. In particular, non-malignant stromal cells, including …
Monocyte regulation in homeostasis and malignancy
Monocytes are progenitors to macrophages and a subclass of dendritic cells (monocyte-
derived dendritic cells, MoDCs), but they also act as circulating sensors that respond to …
derived dendritic cells, MoDCs), but they also act as circulating sensors that respond to …
[HTML][HTML] Tumor microenvironment in head and neck squamous cell carcinoma: Functions and regulatory mechanisms
G Wang, M Zhang, M Cheng, X Wang, K Li, J Chen… - Cancer letters, 2021 - Elsevier
The tumor microenvironment has been recently reported to play a pivotal role in sustaining
tumor cells survival and protecting them from immunotherapy and chemotherapy-induced …
tumor cells survival and protecting them from immunotherapy and chemotherapy-induced …