Cells are repeatedly exposed to environmental or endogenous stresses that can alter
normal cell behavior and increase cell vulnerability. In order to ensure tissue integrity and …

Adenoviruses induce an extensive reorganization of the host cell nucleus during replication.
Such a process results in the assembly of viral and cellular macromolecules into nuclear …

DNA double-strand breaks (DSBs) are repaired at DSB sites. How DSB sites assemble and
how broken DNA is prevented from separating is not understood. Here we uncover that the …

Nuclear actin-based movements have been shown to orchestrate clustering of DNA double-
strand breaks (DSBs) into homology-directed repair domains. Here we describe multiscale …

Abstract Background Chimeric Antigen Receptor (CAR) T cells are now standard of care
(SOC) for some patients with B cell and plasma cell malignancies and could disrupt the …

Recent years have provided considerable insights into the dynamic nature of the cell
nucleus, which is constantly reorganizing its genome, controlling its size and shape, as well …

Microtubules are major cytoskeletal components mediating fundamental cellular processes,
including cell division. Recent evidence suggests that microtubules also regulate the …

A number of studies across different model systems revealed that chromatin undergoes
significant changes in dynamics in response to DNA damage. These include local motion …

Non-polyadenylated mRNAs of replication-dependent histones (RDHs) are synthesized by
RNA polymerase II (Pol II) at histone locus bodies (HLBs). HLBs frequently associate with …

Insertions and deletions (indels) are common sources of structural variation, and insertions
originating from spontaneous DNA lesions are frequent in cancer. We developed a highly …