For over 100 years, clinicians and scientists have been unravelling the consequences of the
A to T substitution in the β-globin gene that produces haemoglobin S, which leads to the …

LSD1 (KDM1A; BHC110; AOF2) was the first protein reported to exhibit histone demethylase
activity and has since been shown to have multiple essential roles in mammalian biology …

Although haemoglobin is a known carrier of oxygen in erythrocytes that functions to transport
oxygen over a long range, its physiological roles outside erythrocytes are largely elusive …

Histone lysine-specific demethylase 1 (LSD1/KDM1A) has become an important and
promising anticancer target since it was first identified in 2004 and specially demethylates …

Abstract Thalassemias (α, β, γ, δ, δβ, and εγδβ) are the most common genetic disorders
worldwide and constitute a heterogeneous group of hereditary diseases characterized by …

Sickle cell disease afflicts millions of people worldwide and approximately 100,000
Americans. Complications are myriad and arise as a result of complex pathological …

The major β‐haemoglobinopathies, sickle cell disease and β‐thalassaemia, represent the
most common monogenic disorders worldwide and a steadily increasing global disease …

Sickle cell disease is a growing health burden afflicting millions around the world. Clinical
observation and laboratory studies have shown that the severity of sickle cell disease is …

Sickle-cell disease affects millions of individuals worldwide, but the global incidence is
concentrated in Africa. The burden of sickle-cell disease is expected to continue to rise over …

Sickle cell disease (SCD) is a heritable disorder caused by β-globin gene mutations.
Induction of fetal γ-globin is an established therapeutic strategy. Recently, epigenetic …