The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …

Janus kinase (JAK) is a family of cytoplasmic non-receptor tyrosine kinases that includes
four members, namely JAK1, JAK2, JAK3, and TYK2. The JAKs transduce cytokine signaling …

The JAK/STAT3 signaling pathway plays an essential role in various types of cancers.
Activation of this pathway leads to increased tumorigenic and metastatic ability, the transition …

Cytokines signal through cell surface receptor dimers to initiate activation of intracellular
Janus kinases (JAKs). We report the 3.6-angstrom–resolution cryo–electron microscopy …

Before it was molecularly cloned in 1994, acute-phase response factor or signal transducer
and activator of transcription (STAT) 3 was the focus of intense research into understanding …

The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway
serves as a paradigm for signal transduction from the extracellular environment to the …

Cytokines, many of which signal through the JAK–STAT (Janus kinase–Signal Transducers
and Activators of Transcription) pathway, play a central role in the pathogenesis of …

The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway
is an evolutionarily conserved mechanism of transmembrane signal transduction that …

Interferons (IFNs) are a family of cytokines with the unique ability to induce cell intrinsic
programs that enhance resistance to viral infection. Induction of an antiviral state at the cell …

Prolonged activation of the type I interferon (IFN-I) pathway leads to autoimmune diseases
such as systemic lupus erythematosus (SLE). Metabolic regulation of cytokine signaling is …