[HTML][HTML] Antibiotic resistance in microbes: History, mechanisms, therapeutic strategies and future prospects

TM Uddin, AJ Chakraborty, A Khusro… - Journal of infection and …, 2021 - Elsevier
Antibiotics have been used to cure bacterial infections for more than 70 years, and these low-
molecular-weight bioactive agents have also been used for a variety of other medicinal …

[HTML][HTML] Antimicrobial resistance: Prevalence, economic burden, mechanisms of resistance and strategies to overcome

T Pulingam, T Parumasivam, AM Gazzali… - European Journal of …, 2022 - Elsevier
Antibiotic resistance is a major health concern globally and has been estimated to cause 10
million deaths worldwide by year 2050 if the current trend of inappropriate and excessive …

Biomaterial-based antimicrobial therapies for the treatment of bacterial infections

PP Kalelkar, M Riddick, AJ García - Nature Reviews Materials, 2022 - nature.com
The rise in antibiotic-resistant bacteria, including strains that are resistant to last-resort
antibiotics, and the limited ability of antibiotics to eradicate biofilms have necessitated the …

Fighting antibiotic resistance—strategies and (pre) clinical developments to find new antibacterials

S Walesch, J Birkelbach, G Jézéquel, FPJ Haeckl… - EMBO …, 2023 - embopress.org
Antibacterial resistance is one of the greatest threats to human health. The development of
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …

Chemically modified and conjugated antimicrobial peptides against superbugs

W Li, F Separovic, NM O'Brien-Simpson… - Chemical Society …, 2021 - pubs.rsc.org
Antimicrobial resistance (AMR) is one of the greatest threats to human health that, by 2050,
will lead to more deaths from bacterial infections than cancer. New antimicrobial agents …

[ΒΙΒΛΙΟ][B] 2019 antibacterial agents in clinical development: an analysis of the antibacterial clinical development pipeline

World Health Organization - 2020 - books.google.com
Some rights reserved. This work is available under the Creative Commons Attribution-
NonCommercial-ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https …

[HTML][HTML] Antibiotics: past, present and future

MI Hutchings, AW Truman, B Wilkinson - Current opinion in microbiology, 2019 - Elsevier
The first antibiotic, salvarsan, was deployed in 1910. In just over 100 years antibiotics have
drastically changed modern medicine and extended the average human lifespan by 23 …

Analysis of the clinical pipeline of treatments for drug-resistant bacterial infections: despite progress, more action is needed

MS Butler, V Gigante, H Sati, S Paulin… - Antimicrobial agents …, 2022 - Am Soc Microbiol
There is an urgent global need for new strategies and drugs to control and treat multidrug-
resistant bacterial infections. In 2017, the World Health Organization (WHO) released a list of …

Antimicrobial peptides: Application informed by evolution

BP Lazzaro, M Zasloff, J Rolff - Science, 2020 - science.org
BACKGROUND Antimicrobial peptides (AMPs) are small proteins with potent antibacterial,
antiviral, and antifungal activity. AMPs are ubiquitous among multicellular eukaryotes, with …

Antibiotic‐free antibacterial strategies enabled by nanomaterials: progress and perspectives

Y Wang, Y Yang, Y Shi, H Song, C Yu - Advanced Materials, 2020 - Wiley Online Library
Bacterial infection is one of the top ten leading causes of death globally and the worst killer
in low‐income countries. The overuse of antibiotics leads to ever‐increasing antibiotic …