The neural crest (NC) is a transient, multipotent and migratory cell population that generates
an astonishingly diverse array of cell types during vertebrate development. These cells …

Gli proteins are transcriptional effectors of the Hedgehog signaling pathway. They play key
roles in the development of many organs and tissues, and are deregulated in birth defects …

The hedgehog (Hh) family comprises sonic hedgehog (Shh), Indian hedgehog (Ihh), and
desert hedgehog (Dhh), which are versatile signaling molecules involved in a wide …

Polydactyly, also known as hyperdactyly or hexadactyly is the most common hereditary limb
anomaly characterized by extra fingers or toes, with various associated morphologic …

Objective: This study collects what is known about the inheritance underpinnings of
syndromic and non-syndromic polydactylies and highlights dactyly presentations with …

GLI transcription factors have important roles in intracellular signaling cascade, acting as the
main mediators of the HH-GLI signaling pathway. This is one of the major developmental …

Polydactyly or polydactylism, also known as a hyperdactyly, is a congenital limb defect with
various morphologic phenotypes. Apart from physical and functional impairments, the …

Preconception environmental conditions have been demonstrated to shape sperm
epigenetics and subsequently offspring health and development. Our previous findings in …

PRKACA and PRKACB code for two catalytic subunits (Cα and Cβ) of cAMP-dependent
protein kinase (PKA), a pleiotropic holoenzyme that regulates numerous fundamental …

Polydactyly or hexadactyly is characterized by an extra digit/toe with or without a bone.
Currently, variants in ten genes have been implicated in the non-syndromic form of …