Long QT and short QT syndromes (LQTS and SQTS) are cardiac repolarization
abnormalities that are characterized by length perturbations of the QT interval as measured …

A variety of inherited human disorders affecting skeletal muscle contraction, heart rhythm,
and nervous system function have been traced to mutations in genes encoding voltage …

Pathogenic variants in the voltage-gated sodium channel gene family lead to early onset
epilepsies, neurodevelopmental disorders, skeletal muscle channelopathies, peripheral …

Drug-induced long QT syndrome is characterized by a prolonged corrected QT interval
(QTc) and increased risk of a polymorphic ventricular tachycardia known as torsade de …

Aims Acquired long QT syndrome (aLQTS) exhibits QT prolongation and Torsades de
Pointes ventricular tachycardia triggered by drugs, hypokalaemia, or bradycardia …

Marked QT prolongation and torsades de pointes can occur not only in the congenital long
QT syndromes (LQTSs) but also as a consequence of environmental stimuli, notably …

Torsades de pointes is a potentially lethal arrhythmia that occasionally appears as an
adverse effect of pharmacotherapy. Recently developed understanding of the underlying …

Aims To assess the association between the use of non-cardiac QTc-prolonging drugs and
the risk of sudden cardiac death. Methods and results A population-based case–control …

Torsades de pointes (TdP) is a malignant polymorphic ventricular tachyarrhythmia that can
be caused by drugs that induce electrophysiological changes. Although the number of drugs …

Phenotypic overlap of type 3 long QT syndrome (LQT3) with Brugada syndrome (BrS) is
observed in some carriers of mutations in the Na channel SCN5A. While this overlap is …