Diabetic nephropathy (DN) is the most common cause of end-stage kidney disease
worldwide, and is associated with increased morbidity and mortality in patients with both …

Using a short-duration step protocol and continuous indirect calorimetry, whole-body rates of
fat and carbohydrate oxidation can be estimated across a range of exercise workloads …

Key points• Several biochemical measures of mitochondrial components are used as
biomarkers of mitochondrial content and muscle oxidative capacity. However, no studies …

In recent years, we've developed a much better grasp of the biological and other factors
associated with the development of obesity. Reflecting our evolving understanding of …

Insulin resistance precedes and predicts the onset of type 2 diabetes (T2D) in susceptible
humans, underscoring its important role in the complex pathogenesis of this disease. Insulin …

Objective To investigate the effects of high-intensity interval training (HIIT) and sprint interval
training (SIT) on fat oxidation during exercise (FatOx) and how they compare with the effects …

Mitochondrial dysfunction has emerged as a central pathomechanism in the setting of
obesity and diabetes mellitus, linking these intertwined pathologies that share insulin …

Based on evidence that patients with type 2 diabetes (T2DM), obese insulin-resistant
individuals, and lean insulin-resistant offspring of parents with T2DM have∼ 30% less …

Disturbances in fat oxidation have been associated with an increased risk of obesity and
metabolic disorders such as insulin resistance. There is large intersubject variability in the …

Maximal fat oxidation during exercise (MFO) and the exercise intensity eliciting MFO
(Fatmax) are considered biological markers of metabolic health and performance. A wide …