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The implications of exosomes in pregnancy: emerging as new diagnostic markers and therapeutics targets
Extracellular vehicles (EVs) are a heterogeneous group of cell and membranous particles
originating from different cell compartments. EVs participate in many essential physiological …
originating from different cell compartments. EVs participate in many essential physiological …
The exosome: a review of current therapeutic roles and capabilities in human reproduction
Abstract Exosomes are nano-vesicles (30–150 nm) which may be useful as therapeutic
delivery vehicles and as diagnostic biomarkers. Exosomes are produced naturally within the …
delivery vehicles and as diagnostic biomarkers. Exosomes are produced naturally within the …
Malaria in pregnancy: from placental infection to its abnormal development and damage
CLL Chua, SKM Khoo, JLE Ong… - Frontiers in …, 2021 - frontiersin.org
Malaria remains a global health burden with Plasmodium falciparum accounting for the
highest mortality and morbidity. Malaria in pregnancy can lead to the development of …
highest mortality and morbidity. Malaria in pregnancy can lead to the development of …
Role of transforming growth factor-β1 in regulating fetal-maternal immune tolerance in normal and pathological pregnancy
D Yang, F Dai, M Yuan, Y Zheng, S Liu… - Frontiers in …, 2021 - frontiersin.org
Transforming growth factor-β (TGF-β) is composed of three isoforms, TGF-β1, TGF-β2, and
TGF-β3. TGF-β1 is a cytokine with multiple biological functions that has been studied …
TGF-β3. TGF-β1 is a cytokine with multiple biological functions that has been studied …
[HTML][HTML] Trophoblast cell subtypes and dysfunction in the placenta of individuals with preeclampsia revealed by single-cell RNA sequencing
W Zhou, H Wang, Y Yang, F Guo, B Yu, Z Su - Molecules and cells, 2022 - Elsevier
Trophoblasts, important functional cells in the placenta, play a critical role in maintaining
placental function. The heterogeneity of trophoblasts has been reported, but little is known …
placental function. The heterogeneity of trophoblasts has been reported, but little is known …
Interdisciplinary fetal-neonatal neurology training applies neural exposome perspectives to neurology principles and practice
MS Scher - Frontiers in neurology, 2024 - frontiersin.org
An interdisciplinary fetal-neonatal neurology (FNN) program over the first 1,000 days
teaches perspectives of the neural exposome that are applicable across the life span. This …
teaches perspectives of the neural exposome that are applicable across the life span. This …
Zika virus modulates mitochondrial dynamics, mitophagy, and mitochondria-derived vesicles to facilitate viral replication in trophoblast cells
JK Lee, OS Shin - Frontiers in immunology, 2023 - frontiersin.org
Zika virus (ZIKV) remains a global public health threat with the potential risk of a future
outbreak. Since viral infections are known to exploit mitochondria-mediated cellular …
outbreak. Since viral infections are known to exploit mitochondria-mediated cellular …
The functional roles of protein glycosylation in human maternal–fetal crosstalk
BACKGROUND The establishment of maternal–fetal crosstalk is vital to a successful
pregnancy. Glycosylation is a post-translational modification in which glycans …
pregnancy. Glycosylation is a post-translational modification in which glycans …
BCL6, a key oncogene, in the placenta, pre-eclampsia and endometriosis
BACKGROUND The key oncogene B-cell lymphoma 6 (BCL6) drives malignant progression
by promoting proliferation, overriding DNA damage checkpoints and blocking cell terminal …
by promoting proliferation, overriding DNA damage checkpoints and blocking cell terminal …
Placental exosomes as biomarkers for maternal diseases: current advances in isolation, characterization, and detection
Serving as the interface between fetal and maternal circulation, the placenta plays a critical
role in fetal growth and development. Placental exosomes are small membrane-bound …
role in fetal growth and development. Placental exosomes are small membrane-bound …