The implications of exosomes in pregnancy: emerging as new diagnostic markers and therapeutics targets

M Ghafourian, R Mahdavi, Z Akbari Jonoush… - Cell Communication and …, 2022 - Springer
Extracellular vehicles (EVs) are a heterogeneous group of cell and membranous particles
originating from different cell compartments. EVs participate in many essential physiological …

The exosome: a review of current therapeutic roles and capabilities in human reproduction

M Dimik, P Abeysinghe, J Logan, M Mitchell - Drug Delivery and …, 2023 - Springer
Abstract Exosomes are nano-vesicles (30–150 nm) which may be useful as therapeutic
delivery vehicles and as diagnostic biomarkers. Exosomes are produced naturally within the …

Malaria in pregnancy: from placental infection to its abnormal development and damage

CLL Chua, SKM Khoo, JLE Ong… - Frontiers in …, 2021 - frontiersin.org
Malaria remains a global health burden with Plasmodium falciparum accounting for the
highest mortality and morbidity. Malaria in pregnancy can lead to the development of …

Role of transforming growth factor-β1 in regulating fetal-maternal immune tolerance in normal and pathological pregnancy

D Yang, F Dai, M Yuan, Y Zheng, S Liu… - Frontiers in …, 2021 - frontiersin.org
Transforming growth factor-β (TGF-β) is composed of three isoforms, TGF-β1, TGF-β2, and
TGF-β3. TGF-β1 is a cytokine with multiple biological functions that has been studied …

[HTML][HTML] Trophoblast cell subtypes and dysfunction in the placenta of individuals with preeclampsia revealed by single-cell RNA sequencing

W Zhou, H Wang, Y Yang, F Guo, B Yu, Z Su - Molecules and cells, 2022 - Elsevier
Trophoblasts, important functional cells in the placenta, play a critical role in maintaining
placental function. The heterogeneity of trophoblasts has been reported, but little is known …

Interdisciplinary fetal-neonatal neurology training applies neural exposome perspectives to neurology principles and practice

MS Scher - Frontiers in neurology, 2024 - frontiersin.org
An interdisciplinary fetal-neonatal neurology (FNN) program over the first 1,000 days
teaches perspectives of the neural exposome that are applicable across the life span. This …

Zika virus modulates mitochondrial dynamics, mitophagy, and mitochondria-derived vesicles to facilitate viral replication in trophoblast cells

JK Lee, OS Shin - Frontiers in immunology, 2023 - frontiersin.org
Zika virus (ZIKV) remains a global public health threat with the potential risk of a future
outbreak. Since viral infections are known to exploit mitochondria-mediated cellular …

The functional roles of protein glycosylation in human maternal–fetal crosstalk

J Zhong, J Li, GJ Burton, H Koistinen… - Human …, 2024 - academic.oup.com
BACKGROUND The establishment of maternal–fetal crosstalk is vital to a successful
pregnancy. Glycosylation is a post-translational modification in which glycans …

BCL6, a key oncogene, in the placenta, pre-eclampsia and endometriosis

F Louwen, NN Kreis, A Ritter, A Friemel… - Human reproduction …, 2022 - academic.oup.com
BACKGROUND The key oncogene B-cell lymphoma 6 (BCL6) drives malignant progression
by promoting proliferation, overriding DNA damage checkpoints and blocking cell terminal …

Placental exosomes as biomarkers for maternal diseases: current advances in isolation, characterization, and detection

CM Nguyen, M Sallam, MS Islam, K Clack, N Soda… - ACS …, 2023 - ACS Publications
Serving as the interface between fetal and maternal circulation, the placenta plays a critical
role in fetal growth and development. Placental exosomes are small membrane-bound …