Impact of advanced paternal age on fertility and risks of genetic disorders in offspring

A Kaltsas, E Moustakli, A Zikopoulos, I Georgiou… - Genes, 2023 - mdpi.com
The average age of fathers at first pregnancy has risen significantly over the last decade
owing to various variables, including a longer life expectancy, more access to contraception …

Advanced maternal age and adverse pregnancy outcomes: A systematic review and meta-analysis

SC Lean, H Derricott, RL Jones, AEP Heazell - PloS one, 2017 - journals.plos.org
Background Advanced maternal age (AMA;≥ 35 years) is an increasing trend and is
reported to be associated with various pregnancy complications. Objective To determine the …

Lifestyle and fertility: the influence of stress and quality of life on male fertility

A Ilacqua, G Izzo, GP Emerenziani, C Baldari… - Reproductive Biology …, 2018 - Springer
Background Male infertility is a widespread condition among couples. In about 50% of
cases, couple infertility is attributable to the male partner, mainly due to a failure in …

Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring

R Sharma, A Agarwal, VK Rohra, M Assidi… - Reproductive Biology …, 2015 - Springer
Over the last decade, there has been a significant increase in average paternal age when
the first child is conceived, either due to increased life expectancy, widespread use of …

The effect of paternal factors on perinatal and paediatric outcomes: a systematic review and meta-analysis

NB Oldereid, UB Wennerholm, A Pinborg… - Human reproduction …, 2018 - academic.oup.com
BACKGROUND Maternal factors, including increasing childbearing age and various life-
style factors, are associated with poorer short-and long-term outcomes for children, whereas …

Association of paternal age with perinatal outcomes between 2007 and 2016 in the United States: population based cohort study

YS Khandwala, VL Baker, GM Shaw, DK Stevenson… - bmj, 2018 - bmj.com
Objective To evaluate the impact of advanced paternal age on maternal and perinatal
outcomes in the United States. Design Retrospective, population based cohort study. Setting …

Advanced paternal age, infertility, and reproductive risks: a review of the literature

JS Brandt, MA Cruz Ithier, T Rosen… - Prenatal …, 2019 - Wiley Online Library
Advanced paternal age (APA) is associated with infertility and other reproductive risks.
Studies looking at APA and outcomes have used different paternal age cut‐offs, which has …

The “Bad Father”: Paternal Role in Biology of Pregnancy and in Birth Outcome

SR Giannubilo, D Marzioni, G Tossetta, R Montironi… - Biology, 2024 - mdpi.com
Simple Summary Human reproduction, as well as that of all mammals, involves the union of
two cells, the male sperm and the female egg, which give rise to a new organism that will …

[HTML][HTML] Is advanced paternal age a health risk for the offspring?

AMN Andersen, SK Urhoj - Fertility and Sterility, 2017 - Elsevier
In this article we review the epidemiologic evidence for adverse health effects in offspring of
fathers of advanced age. First the evidence regarding fetal survival is addressed, and …

How to overcome male infertility after 40: Influence of paternal age on fertility

S Belloc, A Hazout, A Zini, P Merviel, R Cabry… - Maturitas, 2014 - Elsevier
The recent trend toward delayed parenthood raises major safety concerns because of the
adverse effects of aging on couple fertility. Studies have demonstrated that aging clearly …