Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids
RNA–DNA hybrids are generated during transcription, DNA replication and DNA repair and
are crucial intermediates in these processes. When RNA–DNA hybrids are stably formed in …
are crucial intermediates in these processes. When RNA–DNA hybrids are stably formed in …
Human PCNA structure, function, and interactions
Proliferating cell nuclear antigen (PCNA) is an essential factor in DNA replication and repair.
It forms a homotrimeric ring that embraces the DNA and slides along it, anchoring DNA …
It forms a homotrimeric ring that embraces the DNA and slides along it, anchoring DNA …
Direct visualization of transcription-replication conflicts reveals post-replicative DNA: RNA hybrids
H Stoy, K Zwicky, D Kuster, KS Lang… - Nature Structural & …, 2023 - nature.com
Transcription-replication collisions (TRCs) are crucial determinants of genome instability. R-
loops were linked to head-on TRCs and proposed to obstruct replication fork progression …
loops were linked to head-on TRCs and proposed to obstruct replication fork progression …
RNase H2, mutated in Aicardi‐Goutières syndrome, resolves co-transcriptional R-loops to prevent DNA breaks and inflammation
RNase H2 is a specialized enzyme that degrades RNA in RNA/DNA hybrids and deficiency
of this enzyme causes a severe neuroinflammatory disease, Aicardi Goutières syndrome …
of this enzyme causes a severe neuroinflammatory disease, Aicardi Goutières syndrome …
Replication-coupled DNA repair
D Cortez - Molecular cell, 2019 - cell.com
The replisome quickly and accurately copies billions of DNA bases each cell division cycle.
However, it can make errors, especially when the template DNA is damaged. In these cases …
However, it can make errors, especially when the template DNA is damaged. In these cases …
[HTML][HTML] Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development
The presence of ribonucleotides in genomic DNA is undesirable given their increased
susceptibility to hydrolysis. Ribonuclease (RNase) H enzymes that recognize and process …
susceptibility to hydrolysis. Ribonuclease (RNase) H enzymes that recognize and process …
[HTML][HTML] Functions of replication protein A as a sensor of R loops and a regulator of RNaseH1
R loop, a transcription intermediate containing RNA: DNA hybrids and displaced single-
stranded DNA (ssDNA), has emerged as a major source of genomic instability. RNaseH1 …
stranded DNA (ssDNA), has emerged as a major source of genomic instability. RNaseH1 …
Regulation of PCNA–protein interactions for genome stability
N Mailand, I Gibbs-Seymour… - Nature reviews Molecular …, 2013 - nature.com
Proliferating cell nuclear antigen (PCNA) has a central role in promoting faithful DNA
replication, providing a molecular platform that facilitates the myriad protein–protein and …
replication, providing a molecular platform that facilitates the myriad protein–protein and …
Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components
C Alabert, JC Bukowski-Wills, SB Lee… - Nature cell …, 2014 - nature.com
To maintain genome function and stability, DNA sequence and its organization into
chromatin must be duplicated during cell division. Understanding how entire chromosomes …
chromatin must be duplicated during cell division. Understanding how entire chromosomes …
[HTML][HTML] Counteracting chromatin effects of a splicing-correcting antisense oligonucleotide improves its therapeutic efficacy in spinal muscular atrophy
Spinal muscular atrophy (SMA) is a motor-neuron disease caused by mutations of the SMN1
gene. The human paralog SMN2, whose exon 7 (E7) is predominantly skipped, cannot …
gene. The human paralog SMN2, whose exon 7 (E7) is predominantly skipped, cannot …