Copper is an essential trace element in biological systems, maintaining the activity of
enzymes and the function of transcription factors. However, at high concentrations, copper …

Programmed cell death (PCD) is the universal process that maintains cellular homeostasis
and regulates all living systems' development, health and disease. Out of all, apoptosis is …

The concept of using phytochemicals has ushered in a new revolution in pharmaceuticals.
Naturally occurring polyphenols (like curcumin, morin, resveratrol, etc.) have gained …

Due to the sustained proliferative potential of cancer cells, inducing cell death is a potential
strategy for cancer therapy. Paraptosis is a mode of cell death characterized by endoplasmic …

Standard anti-cancer therapies promote tumor growth suppression mainly via induction of
apoptosis. However, in most cases cancer cells acquire the ability to escape apoptotic cell …

Mitogen‐activated protein kinase (MAPK) activation by natural compounds is known to be
involved in the induction of apoptosis, paraptosis, and autophagy. Cannabidiol (CBD), a …

Given the problems with malignant cancer cells showing innate and acquired resistance to
apoptosis, we need alternative means to induce cell death in cancer. Paraptosis is a type of …

Pancreatic cancer is one of the deadliest diseases with a poor prognosis and a five‐survival
rate. The STAT3 pathway is hyperactivated which contributes to the sustained proliferative …

Abstract Auranofin (AF), a gold (I)-containing phosphine compound, is being investigated for
oncological application as a repurposed drug. We show here that 4~ 5 µM AF induces …

Cell death can be classified into two primary categories: accidental cell death and regulated
cell death (RCD). Within RCD, there are distinct apoptotic and non-apoptotic cell death …