The signal pathways and treatment of cytokine storm in COVID-19

L Yang, X **e, Z Tu, J Fu, D Xu, Y Zhou - Signal transduction and …, 2021 - nature.com
Abstract The Coronavirus Disease 2019 (COVID-19) pandemic has become a global crisis
and is more devastating than any other previous infectious disease. It has affected a …

Cytokine release syndrome and associated neurotoxicity in cancer immunotherapy

EC Morris, SS Neelapu, T Giavridis… - Nature Reviews …, 2022 - nature.com
A paradigm shift has recently occurred in the field of cancer therapeutics. Traditional
anticancer agents, such as chemotherapy, radiotherapy and small-molecule drugs targeting …

Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial

E Kyriazopoulou, G Poulakou, H Milionis, S Metallidis… - Nature medicine, 2021 - nature.com
Early increase of soluble urokinase plasminogen activator receptor (suPAR) serum levels is
indicative of increased risk of progression of coronavirus disease 2019 (COVID-19) to …

Calming the cytokine storm in COVID-19

RQ Cron, R Caricchio, WW Chatham - Nature medicine, 2021 - nature.com
Calming the cytokine storm in COVID-19 | Nature Medicine Skip to main content Thank you for
visiting nature.com. You are using a browser version with limited support for CSS. To obtain the …

Effect of anakinra on mortality in patients with COVID-19: a systematic review and patient-level meta-analysis

E Kyriazopoulou, T Huet, G Cavalli, A Gori… - The Lancet …, 2021 - thelancet.com
Background Anakinra might improve the prognosis of patients with moderate to severe
COVID-19 (ie, patients requiring oxygen supplementation but not yet receiving organ …

COVID-19 induces CNS cytokine expression and loss of hippocampal neurogenesis

AL Soung, A Vanderheiden, AS Nordvig, CA Sissoko… - Brain, 2022 - academic.oup.com
Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
associated with acute and postacute cognitive and neuropsychiatric symptoms including …

Coronavirus disease 2019 as cause of viral sepsis: a systematic review and meta-analysis

E Karakike, EJ Giamarellos-Bourboulis… - Critical care …, 2021 - journals.lww.com
Objective: Coronavirus disease 2019 is a heterogeneous disease most frequently causing
respiratory tract infection, which can induce respiratory failure and multiple organ …

[HTML][HTML] COVID-19 induces neuroinflammation and loss of hippocampal neurogenesis

R Klein, A Soung, C Sissoko, A Nordvig, P Canoll… - Research …, 2021 - ncbi.nlm.nih.gov
Abstract Infection with the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-
2) is associated with onset of neurological and psychiatric symptoms during and after the …

Treatment of MIS-C in children and adolescents

S Mahmoud, M El-Kalliny, A Kotby… - Current pediatrics …, 2022 - Springer
Abstract Purpose of Review Different treatment approaches have been described for the
management of COVID-19-related multisystem inflammatory syndrome in children (MIS-C) …

Efficacy of early anti-inflammatory treatment with high doses of intravenous anakinra with or without glucocorticoids in patients with severe COVID-19 pneumonia

E Pontali, S Volpi, A Signori, G Antonucci… - Journal of Allergy and …, 2021 - Elsevier
Background IL-1 plays a pivotal role in the inflammatory response during cytokine storm
syndromes. Objective Our aim was to analyze the efficacy and safety of early anti …