The light sensor of vertebrate scotopic (low-light) vision, rhodopsin, is a G-protein-coupled
receptor comprising a polypeptide chain with bound chromophore, 11-cis-retinal, that …

Molecular dynamics (MD) simulations monitor time-resolved motions of macromolecules.
While visualization of MD trajectories allows an instant and intuitive understanding of …

The κ-opioid receptor (KOR) represents a highly desirable therapeutic target for treating not
only pain but also addiction and affective disorders. However, the development of KOR …

The class A adenosine A1 receptor (A1R) is a G-protein-coupled receptor that preferentially
couples to inhibitory Gi/o heterotrimeric G proteins, has been implicated in numerous …

Muscarinic acetylcholine receptors are G protein–coupled receptors that respond to
acetylcholine and play important signaling roles in the nervous system. There are five …

G-protein-coupled receptors mediate the biological effects of many hormones and
neurotransmitters and are important pharmacological targets. They transmit their signals to …

G-protein-coupled receptors comprise the largest family of mammalian transmembrane
receptors. They mediate numerous cellular pathways by coupling with downstream …

Over the past three years (2020–2022) more structures of GPCRs have been determined
than in the previous twenty years (2000–2019), primarily of GPCR complexes that are large …

The selective coupling of G-protein-coupled receptors (GPCRs) to specific G proteins is
critical to trigger the appropriate physiological response. However, the determinants of …

Single-particle cryo-electron microscopy (cryo-EM) has recently enabled high-resolution
structure determination of numerous biological macromolecular complexes. Despite this …