This review provides an account of our explorations into oligosaccharide and
glycoconjugate construction for the creation and evaluation of vaccines based on …

Identifying the functional roles of carbohydrates in biological systems has been an area of
intense study in recent years. Although carbohydrates were once viewed only as inert …

Glycosylation, and especially O-linked glycosylation, remains a critical blind spot in the
understanding of post-translational modifications. Due to their nature as proteins defined by …

Mucin-type O-linked glycosylation is a fundamental post-translational modification that is
involved in a variety of important biological processes. However, the lack of chemical tools to …

The cystine knot three-dimensional structure is found in many extracellular molecules and is
conserved among divergent species. The identification of proteins with a cystine knot …

Nanoscale analysis may be used to design new types of mucoadhesive polymers.
Understanding of the surface interactions between hydrophilic polymer surfaces and mucins …

Despite the omnipresence of protein glycosylation in nature, little is known about how the
attachment of carbohydrates affects peptide and protein activity. One reason is the lack of a …

Cancer is currently one of the world's most serious public health problems. Significant efforts
are being made to develop new strategies that can eradicate tumours selectively without …

Investigations into the roles of protein glycosylation have revealed functions such as
modulating protein structure and localization, cell–cell recognition, and signaling in …

The structural characteristics of a mucin glycopeptide motif derived from the N-terminal
fragment STTAV of the cell surface glycoprotein CD43 have been investigated by NMR. In …