Cyclin-dependent kinases (Cdks) are serine/threonine kinases and their catalytic activities
are modulated by interactions with cyclins and Cdk inhibitors (CKIs). Close cooperation …

Over the past two decades there has been a great deal of interest in the development of
inhibitors of the cyclin-dependent kinases (CDKs). This attention initially stemmed from …

Abstract Cyclin-dependent kinase 7 (CDK7), along with cyclin H and MAT1, forms the CDK-
activating complex (CAK), which directs progression through the cell cycle via T-loop …

Summary Cyclin-dependent kinase 7 (CDK7) is a central regulator of the cell cycle and gene
transcription. However, little is known about its impact on genomic instability and cancer …

Ageing is the main risk factor for major non-communicable chronic lung diseases, including
chronic obstructive pulmonary disease, most forms of lung cancer and idiopathic pulmonary …

Summary Cyclin-dependent kinase 7 (CDK7), part of the general transcription factor TFIIH,
promotes gene transcription by phosphorylating the C-terminal domain of RNA polymerase …

TFIIH is a 10‐subunit complex that regulates RNA polymerase II (pol II) transcription but also
serves other important biological roles. Although much remains unknown about TFIIH …

Recent reports indicate that some cancer types are especially sensitive to transcription
inhibition, suggesting that targeting the transcriptional machinery provides new approaches …

While targeting experiments carried out on the genes encoding many cell cycle regulators
have challenged our views of cell cycle control, they also suggest that redundancy might not …

The transcription cycle of RNA polymerase II (Pol II) is regulated by a set of cyclin-dependent
kinases (CDKs). Cdk7, associated with the transcription initiation factor TFIIH, is both an …