Biomedical and biochemical applications of self-assembled metallacycles and metallacages

TR Cook, V Vajpayee, MH Lee, PJ Stang… - Accounts of chemical …, 2013 - ACS Publications
Metal ions and metal complexes with organic molecules are ubiquitous in nature. Bulk metal
ions of Na, K, Mg, and Ca constitute as much as 1% of human body weight. The remaining …

Recent developments of supramolecular metal-based structures for applications in cancer therapy and imaging

A Pöthig, A Casini - Theranostics, 2019 - pmc.ncbi.nlm.nih.gov
The biomedical application of discrete supramolecular metal-based structures, including
supramolecular coordination complexes (SCCs), is still an emergent field of study. However …

Metal–organic polyhedron capped with cucurbit [8] uril delivers doxorubicin to cancer cells

SK Samanta, D Moncelet, V Briken… - Journal of the American …, 2016 - ACS Publications
Self-assembly of ligand 1 and Pd (NO3) 2 delivers Fujita-type metal–organic polyhedron
(MOP) 3 which bears 24 covalently attached methyl viologen units on its external surface, as …

Metal‐Modified Nucleic Acids: Metal‐Mediated Base Pairs, Triples, and Tetrads

S Naskar, R Guha, J Mueller - … Chemie International Edition, 2020 - Wiley Online Library
The incorporation of metal ions into nucleic acids by means of metal‐mediated base pairs
represents a promising and prominent strategy for the site‐specific decoration of these self …

Exploring the cellular accumulation of metal complexes

CA Puckett, RJ Ernst, JK Barton - Dalton Transactions, 2010 - pubs.rsc.org
Transition metal complexes offer great potential as diagnostic and therapeutic agents, and a
growing number of biological applications have been explored. To be effective, these …

Optically pure, water-stable metallo-helical 'flexicate'assemblies with antibiotic activity

SE Howson, A Bolhuis, V Brabec, GJ Clarkson… - Nature …, 2012 - nature.com
The helicates—chiral assemblies of two or more metal atoms linked by short or relatively
rigid multidentate organic ligands—may be regarded as non-peptide mimetics of α-helices …

Interactions of small molecules with DNA junctions

KT McQuaid, A Pipier, CJ Cardin… - Nucleic Acids …, 2022 - academic.oup.com
The four natural DNA bases (A, T, G and C) associate in base pairs (A= T and G≡ C),
allowing the attached DNA strands to assemble into the canonical double helix of DNA (or …

A triangular platinum (II) multinuclear complex with cytotoxicity towards breast cancer stem cells

A Eskandari, A Kundu, S Ghosh… - Angewandte …, 2019 - Wiley Online Library
The preparation of multinuclear metal complexes offers a route to novel anticancer agents
and delivery systems. The potency of a novel triangular multinuclear complex containing …

'Click'to functionalise: synthesis, characterisation and enhancement of the physical properties of a series of exo-and endo-functionalised Pd 2 L 4 nanocages

JEM Lewis, ABS Elliott, CJ McAdam, KC Gordon… - Chemical …, 2014 - pubs.rsc.org
The synthesis of self-assembled metallosupramolecular architectures has been of steadily
growing interest in recent years due to their diverse applications. Appending additional …

Asymmetric triplex metallohelices with high and selective activity against cancer cells

AD Faulkner, RA Kaner, QMA Abdallah, G Clarkson… - Nature Chemistry, 2014 - nature.com
Small cationic amphiphilic α-helical peptides are emerging as agents for the treatment of
cancer and infection, but they are costly and display unfavourable pharmacokinetics. Helical …