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Biological constraints on GWAS SNPs at suggestive significance thresholds reveal additional BMI loci
To uncover novel significant association signals (p< 5× 10− 8), genome-wide association
studies (GWAS) requires increasingly larger sample sizes to overcome statistical correction …
studies (GWAS) requires increasingly larger sample sizes to overcome statistical correction …
[HTML][HTML] 3D promoter architecture re-organization during iPSC-derived neuronal cell differentiation implicates target genes for neurodevelopmental disorders
Neurodevelopmental disorders are thought to arise from interrupted development of the
brain at an early age. Genome-wide association studies (GWAS) have identified hundreds of …
brain at an early age. Genome-wide association studies (GWAS) have identified hundreds of …
Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene map** of relevant complex traits
The hypothalamus regulates metabolic homeostasis by influencing behavior and endocrine
systems. Given its role governing key traits, such as body weight and reproductive timing …
systems. Given its role governing key traits, such as body weight and reproductive timing …
Integrative transcriptomic analysis of SLE reveals IFN-driven cross-talk between immune cells
The systemic lupus erythematosus (SLE) is an incurable autoimmune disease
disproportionately affecting women and may lead to damage in multiple different organs …
disproportionately affecting women and may lead to damage in multiple different organs …